Drug Interactions between Myhibbin and Prevacid NapraPAC 375
This report displays the potential drug interactions for the following 2 drugs:
- Myhibbin (mycophenolate mofetil)
- Prevacid NapraPAC 375 (lansoprazole/naproxen)
Interactions between your drugs
naproxen lansoprazole
Applies to: Prevacid NapraPAC 375 (lansoprazole / naproxen) and Prevacid NapraPAC 375 (lansoprazole / naproxen)
GENERALLY AVOID: Theoretically, proton pump inhibitors may decrease the gastrointestinal absorption of enteric-coated naproxen, which requires an acidic environment for dissolution. The proposed mechanism is an increase in gastric pH (i.e. decreased gastric acidity) induced by proton pump inhibitors. In patients treated with proton pump inhibitors, the possibility of a reduced or subtherapeutic response to enteric-coated naproxen should be considered.
MANAGEMENT: Concomitant use of these drugs is generally not recommended.
References
- (2002) "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc
lansoprazole mycophenolate mofetil
Applies to: Prevacid NapraPAC 375 (lansoprazole / naproxen) and Myhibbin (mycophenolate mofetil)
MONITOR: Coadministration with inhibitors of the proton pump (PPIs or potassium-competitive acid blockers [PCABs]) may reduce the bioavailability of mycophenolic acid (MPA) from the administration of mycophenolate mofetil. The exact mechanism of interaction has not been established, but may involve a decrease in MPA solubility at higher gastric pH levels. When single doses of proton pump inhibitors were given to healthy volunteers and multiple doses to transplant patients receiving mycophenolate mofetil, MPA peak plasma concentration (Cmax) was reduced by 30% to 70% and systemic exposure (AUC) by 25% to 35%. The clinical significance is unknown. The interaction does not appear to occur when mycophenolic acid itself is administered. In 12 healthy volunteers, the pharmacokinetics of MPA were observed to be similar when a single 720 mg dose of mycophenolic acid was administered alone and following concomitant administration with pantoprazole, which was administered at a dosage of 40 mg twice daily for 4 days.
MANAGEMENT: Because clinical relevance of this interaction has not been established, PPIs or PCABs should be used with caution in transplant patients receiving mycophenolate mofetil.
References
- (2001) "Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories
- (2004) "Product Information. Myfortic (mycophenolic acid)." Novartis Pharmaceuticals
- (2022) "Product Information. Voquezna Dual Pak (amoxicillin-vonoprazan)." Phathom Pharmaceuticals, Inc
- (2022) "Product Information. Voquezna Triple Pak (amoxicillin/clarithromycin/vonoprazan)." Phathom Pharmaceuticals, Inc
Drug and food interactions
naproxen food
Applies to: Prevacid NapraPAC 375 (lansoprazole / naproxen)
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References
- (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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