Drug Interactions between Mintezol and Veozah
This report displays the potential drug interactions for the following 2 drugs:
- Mintezol (thiabendazole)
- Veozah (fezolinetant)
Interactions between your drugs
thiabendazole fezolinetant
Applies to: Mintezol (thiabendazole) and Veozah (fezolinetant)
CONTRAINDICATED: Coadministration with inhibitors of CYP450 1A2 may significantly increase the plasma concentrations of fezolinetant, which is primarily metabolized by the isoenzyme. In clinical drug interaction studies, fezolinetant was coadministered with fluvoxamine, mexiletine, and cimetidine (potent, moderate, and weak CYP450 1A2 inhibitors, respectively). Fezolinetant peak plasma concentration (Cmax) increased by 80%, 40%, and 30%, respectively, while its systemic exposure (AUC) increased by 840%, 360%, and 100%, respectively.
MANAGEMENT: Concomitant use of fezolinetant with CYP450 1A2 inhibitors is considered contraindicated.
References (1)
- (2023) "Product Information. Veozah (fezolinetant)." Astellas Pharma US, Inc
Drug and food interactions
fezolinetant food
Applies to: Veozah (fezolinetant)
CONTRAINDICATED: Coadministration with inhibitors of CYP450 1A2 such as caffeine may significantly increase the plasma concentrations of fezolinetant, which is primarily metabolized by the isoenzyme. The interaction has not been studied with caffeine but has been reported for other CYP450 1A2 inhibitors. Consumption of caffeine-containing food or beverages (e.g., chocolate, coffee, cola drinks, energy drinks, tea) could result in an interaction with fezolinetant. In clinical drug interaction studies, fezolinetant was coadministered with fluvoxamine, mexiletine, and cimetidine (potent, moderate, and weak CYP450 1A2 inhibitors, respectively). Fezolinetant peak plasma concentration (Cmax) increased by 80%, 40%, and 30%, respectively, while its systemic exposure (AUC) increased by 840%, 360%, and 100%, respectively.
MANAGEMENT: Concomitant use of fezolinetant with CYP450 1A2 inhibitors such as caffeine, including caffeine-containing food or beverages, is considered contraindicated.
References (1)
- (2023) "Product Information. Veozah (fezolinetant)." Astellas Pharma US, Inc
thiabendazole food
Applies to: Mintezol (thiabendazole)
MONITOR: Coadministration with thiabendazole may increase the plasma concentrations of caffeine. The mechanism is thiabendazole inhibition of the CYP450 1A2 metabolism of caffeine. In ten healthy, nonsmoking volunteers, administration of a single 136.5 mg dose of caffeine in combination with a single 500 mg dose of thiabendazole resulted in a nearly 60% increase in the area under the plasma concentration-time curve (AUC) of caffeine compared to administration without thiabendazole. In addition, the half-life of caffeine was increased from 11.9 to 28.6 hours, and oral clearance was reduced by 67% during coadministration with thiabendazole. The formation of paraxanthine from caffeine, which is primarily mediated by CYP450 1A2, was almost completely abolished until after the thiabendazole was cleared from the system.
MANAGEMENT: Patients should be advised that pharmacologic effects of caffeine may be increased during coadministration with thiabendazole.
References (1)
- Bapiro TE, Sayi J, Hasler JA, et al. (2005) "Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans." Eur J Clin Pharmacol, 61, p. 755-61
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
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