Drug interactions between MetroGel and Rozex
|MetroGel (metronidazole topical)|
|Rozex (metronidazole topical)|
Interactions between your drugs
- MetroGel is in the drug class topical anti-rosacea agents.
- MetroGel is used to treat the following conditions:
- Rozex is a member of the drug class topical anti-rosacea agents.
- Rozex is used to treat the following conditions:
Drug and food interactions
Applies to: MetroGel (metronidazole topical), Rozex (metronidazole topical)
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Use of alcohol or products containing alcohol during nitroimidazole therapy may result in a disulfiram-like reaction in some patients. There have been a few case reports involving metronidazole, although data overall are not convincing. The presumed mechanism is inhibition of aldehyde dehydrogenase (ALDH) by metronidazole in a manner similar to disulfiram. Following ingestion of alcohol, inhibition of ALDH results in increased concentrations of acetaldehyde, the accumulation of which can produce an unpleasant physiologic response referred to as the 'disulfiram reaction'. Symptoms include flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion. Severe reactions may result in respiratory depression, cardiovascular collapse, arrhythmia, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death. However, some investigators have questioned the disulfiram-like properties of metronidazole. One study found neither elevations in blood acetaldehyde nor objective or subjective signs of a disulfiram-like reaction to ethanol in six subjects treated with metronidazole (200 mg three times a day for 5 days) compared to six subjects who received placebo.
MANAGEMENT: Because clear evidence is lacking concerning the safety of ethanol use during nitroimidazole therapy, patients should be apprised of the potential for interaction and instructed to avoid alcoholic beverages and products containing alcohol or propylene glycol while using oral, intravenous, or vaginal preparations of a nitroimidazole. Alcoholic beverages should not be consumed for up to 3 days after completion of systemic nitroimidazole therapy.
Therapeutic duplication warnings
The recommended maximum number of medicines in the 'vaginal anti-infectives' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'vaginal anti-infectives' category:
- metronidazole (active ingredient in MetroGel (metronidazole topical))
- metronidazole (active ingredient in Rozex (metronidazole topical))
Drug Interaction Classification
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.