Drug interactions between methotrexate and mifepristone
Interactions between your drugs
- Methotrexate is in the following drug classes: antimetabolites, antipsoriatics, antirheumatics, other immunosuppressants.
- Methotrexate is used to treat the following conditions:
- Acute Lymphoblastic Leukemia
- Acute Lymphocytic Leukemia
- Acute Nonlymphocytic Leukemia
- Bladder Cancer
- Brain Tumor
- Breast Cancer
- Bullous Pemphigoid
- Cervical Cancer
- Cogan's Syndrome
- Colorectal Cancer
- Ectopic Pregnancy
- Esophageal Carcinoma
- Gastric Cancer
- Graft-versus-host disease
- Head and Neck Cancer
- Hodgkin's Lymphoma
- Juvenile Idiopathic Arthritis
- Mantle Cell Lymphoma
- Meningeal Leukemia
- Mycosis Fungoides
- Neoplastic Diseases
- Non-Hodgkin's Lymphoma
- Non-Small Cell Lung Cancer
- Ovarian Cancer
- Pancreatic Cancer
- Pityriasis rubra pilaris
- Psoriatic Arthritis
- Rheumatoid Arthritis
- Small Cell Lung Cancer
- Soft Tissue Sarcoma
- Solid Tumors
- Systemic Sclerosis
- Trophoblastic Disease
- Mifepristone is a member of the following drug classes: progesterone receptor modulators, uterotonic agents.
- Mifepristone is used to treat the following conditions:
Drug and food interactions
Applies to: methotrexate
Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are receiving methotrexate for arthritis, you may want to limit your intake of caffeine-containing foods and medications. Check with your doctor or pharmacist if you have concerns or are uncertain what products may contain caffeine.
Applies to: mifepristone
Food increases the blood levels of this medication. If you are only receiving one or two doses, you may take it without regard to meals. However, if you are receiving the medication for long-term treatment, you should take it with food at the same time everyday to maintain consistent blood levels and effects. Avoid consuming grapefruit or grapefruit juice during treatment, as it may increase blood levels of the medication to undesirable levels and increase the risk of side effects, including headache, dizziness, fatigue, nausea, vomiting, cramping, diarrhea, hypokalemia (low blood potassium), fluid retention, swelling, and high blood pressure. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No therapeutic duplications were found for your selected drugs.
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.