Skip to Content
Is your Crohn's advancing? Three signs to look out for >>

Pentasa (mesalamine) Drug Interactions

A total of 150 drugs are known to interact with Pentasa (mesalamine).

  • 41 major drug interactions
  • 109 moderate drug interactions

Show all medications in the database that may interact with Pentasa (mesalamine).

Check for interactions

Type in a drug name to check for interactions with Pentasa (mesalamine).

Most frequently checked interactions

View interaction reports for Pentasa (mesalamine) and the medicines listed below.

  • Advil (ibuprofen)
  • aspirin (Aspir 81, Ecotrin, Aspirin Low Strength, Acetylsalicylic Acid, Bayer Aspirin, Aspir-Low, Bufferin, Ascriptin, Arthritis Pain, Aspiritab, Aspergum, Fasprin, Halfprin, Easprin, Ecotrin Adult Low Strength, Empirin, Migralex, Aspi-Cor, St. Joseph 81 mg Chewable Aspirin, Bayer Children's Aspirin, Buffered Aspirin, Durlaza, Ecotrin Maximum Strength, Entercote, Bufferin Extra Strength, Ascriptin Enteric, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspirtab, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Low Dose ASA, Bayer Aspirin Extra Strength Plus, Buffex, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, St. Joseph Aspirin, Stanback Analgesic, Norwich Aspirin, Acuprin 81, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Aspirin Lite Coat, Heartline, Bayer Advanced Aspirin, Buffasal)
  • azathioprine (Imuran, Azasan)
  • Benadryl (diphenhydramine)
  • budesonide (Uceris, Pulmicort Turbuhaler, Pulmicort Flexhaler, Entocort EC, Pulmicort Respules, Pulmicort Nebuamp)
  • dicyclomine (Bentyl, Dicyclocot, Bentyl Syrup, Bemote, Byclomine, Di-Spaz, Dibent, Dilomine)
  • Entocort EC (budesonide)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • folic acid (Folvite, FA-8, Folacin-800, FaLessa)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • Humira (adalimumab)
  • hydrochlorothiazide (HydroDIURIL, Microzide, Oretic, Esidrix, Ezide, Aquazide H, Hydro Par, Carozide, Diaqua, Loqua)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • Imodium (loperamide)
  • Imuran (azathioprine)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Euthyrox, Unithroid, Levothyrox, Eutroxsig, Levo-T, Oroxine, L Thyroxine Roche, Levotabs, Novothyrox, Tirosint-Sol, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • mercaptopurine (Purixan, Purinethol)
  • naproxen (Aleve, Naprosyn, Anaprox, Naproxen Sodium DS, EC-Naprosyn, Anaprox-DS, Naprelan, Comfort Pac with Naproxen, Leader Naproxen Sodium, Aflaxen, Midol Extended Relief, Flanax Pain Reliever, Pamprin All Day Relief, All Day Pain Relief, All Day Relief)
  • Nexium (esomeprazole)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • pantoprazole (Protonix, Protonix IV)
  • Paracetamol (acetaminophen)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Meticorten, Orasone, Liquid Pred, Prednicen-M)
  • Protonix (pantoprazole)
  • Remicade (infliximab)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, ConZip, Zydol, Tramal SR, GenRx Tramadol, Zamadol, Ryzolt, Tramedo, Larapam SR, Tramahexal SR, Tramahexal, Zydol XL, Rybix ODT, Ultram ODT)
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)

Pentasa (mesalamine) disease interactions

There are 2 disease interactions with Pentasa (mesalamine) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide