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Drug Interactions between macimorelin and sodium iodide-i-131

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

sodium iodide I-131 macimorelin

Applies to: sodium iodide-i-131 and macimorelin

GENERALLY AVOID: Drugs that may blunt the growth hormone response to macimorelin such as muscarinic antagonists (e.g., atropine), anti-thyroid agents (e.g., propylthiouracil), and growth hormone products may impact the accuracy of the macimorelin diagnostic test.

MANAGEMENT: Concomitant use of drugs that can blunt the response to macimorelin should generally be avoided. A sufficient washout period following discontinuation of these drugs is recommended prior to macimorelin administration. The prescribing information recommends discontinuing growth hormone products for at least one week before administering the macimorelin diagnostic test.

References (1)
  1. (2018) "Product Information. Macrilen (macimorelin)." Aeterna Zentaris

Drug and food interactions

Moderate

sodium iodide I-131 food

Applies to: sodium iodide-i-131

MONITOR: Excessive intake of dietary iodine (e.g., iodised salt) may interfere with adequate uptake of radioiodide by the thyroid .

MANAGEMENT: A diet low in iodine is recommended before initiating therapy with sodium iodide I-131 or I-123.

References (1)
  1. Cerner Multum, Inc. "Australian Product Information."
Moderate

macimorelin food

Applies to: macimorelin

ADJUST DOSING INTERVAL: Food reduces the oral bioavailability of macimorelin. According to the product labeling, administration with a liquid meal decreased macimorelin peak plasma concentration (Cmax) and systemic exposure (AUC) by 55% and 49%, respectively, compared to administration under fasting conditions (i.e., for at least 8 hours).

MANAGEMENT: Macimorelin should be administered after fasting for at least 8 hours.

References (1)
  1. (2018) "Product Information. Macrilen (macimorelin)." Aeterna Zentaris
Moderate

sodium iodide I-131 food

Applies to: sodium iodide-i-131

ADJUST DOSING INTERVAL: Certain drugs may affect the pharmacokinetics, pharmacodynamics, and/or diagnostic results of radioiodides.

MANAGEMENT: Antithyroid agents such as carbimazole or propylthiouracil should generally be withheld for 1 week before administration of sodium iodide I-131 or I-123, and for a few days afterward. Salicylates, steroids, anticoagulants, antihistamines, antiparasitics, penicillins, sulfonamides, tolbutamide, thiopental, and nitroprusside should generally be withheld for 1 week. Amiodarone, lithium, and benzodiazepines should be withheld for at least 4 weeks.

References (1)
  1. (2022) "Product Information. Sodium Iodide I-123 (sodium iodide I-123)." GE Healthcare

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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