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Unithroid (levothyroxine) Drug Interactions

A total of 590 drugs are known to interact with Unithroid (levothyroxine).

  • 546 moderate drug interactions
  • 44 minor drug interactions

Show all medications in the database that may interact with Unithroid (levothyroxine).

Check for interactions

Type in a drug name to check for interactions with Unithroid (levothyroxine).

Most frequently checked interactions

View interaction reports for Unithroid (levothyroxine) and the medicines listed below.

  • amlodipine (Norvasc)
  • aspirin (Aspir 81, Ecotrin, Aspirin Low Strength, Acetylsalicylic Acid, Bayer Aspirin, Aspir-Low, Bufferin, Ascriptin, Arthritis Pain, Aspiritab, Aspergum, Fasprin, Halfprin, Easprin, Ecotrin Adult Low Strength, Empirin, Migralex, Aspi-Cor, St. Joseph 81 mg Chewable Aspirin, Bayer Children's Aspirin, Buffered Aspirin, Durlaza, Ecotrin Maximum Strength, Entercote, Bufferin Extra Strength, Ascriptin Enteric, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspirtab, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Low Dose ASA, Bayer Aspirin Extra Strength Plus, Buffex, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, St. Joseph Aspirin, Stanback Analgesic, Norwich Aspirin, Acuprin 81, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Aspirin Lite Coat, Heartline, Bayer Advanced Aspirin, Buffasal)
  • atorvastatin (Lipitor)
  • bupropion (Wellbutrin, Wellbutrin XL, Wellbutrin SR, Zyban, Buproban, Budeprion, Aplenzin, Forfivo XL, Budeprion XL, Budeprion SR)
  • Cymbalta (duloxetine)
  • Cytomel (liothyronine)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • furosemide (Lasix, Diaqua-2, Lo-Aqua)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • Klonopin (clonazepam)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • Lyrica (pregabalin)
  • metformin (Glucophage, Glumetza, Glucophage XR, Fortamet, Riomet)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, RoxyBond, Percolone, Oxecta, Oxydose, Oxyfast, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol, Dazidox)
  • pantoprazole (Protonix, Protonix IV)
  • Synthroid (levothyroxine)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)

Unithroid (levothyroxine) alcohol/food interactions

There are 3 alcohol/food interactions with Unithroid (levothyroxine)

Unithroid (levothyroxine) disease interactions

There are 5 disease interactions with Unithroid (levothyroxine) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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