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Drug interactions between Levaquin and Methylpred DP

Results for the following 2 drugs:
Levaquin (levofloxacin)
Methylpred DP (methylprednisolone)

Interactions between your drugs

Major

methylprednisolone ↔ levofloxacin

Applies to:Methylpred DP (methylprednisolone) and Levaquin (levofloxacin)

LevoFLOXacin and other medications in its class can cause tendinitis and tendon rupture, and the risk may be increased when combined with a steroid such as methylPREDNISolone. Older adults over 60 years of age and those who have received a kidney, heart, and/or lung transplant may be particularly susceptible. Tendon rupture can occur during or up to several months after finishing levoFLOXacin treatment and may require surgery or result in prolonged disability. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Stop taking levoFLOXacin and call your doctor immediately if you experience pain, swelling, or inflammation of a tendon area such as the back of the ankle, shoulder, biceps, hand, or thumb. You should also avoid exercise or use of the affected area until further instruction from your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

methylprednisolone food

Applies to: Methylpred DP (methylprednisolone)

Grapefruit juice may increase the blood levels and effects of certain medications such as methylPREDNISolone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with methylPREDNISolone. However, if you have been regularly consuming grapefruit or grapefruit juice with methylPREDNISolone, do not alter the amounts of these products in your diet without first talking to your doctor or other healthcare professional. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Moderate

levofloxacin food

Applies to: Levaquin (levofloxacin)

When levoFLOXacin as the oral solution is given with enteral (tube) feedings, levoFLOXacin may not work as well. You could interrupt the feeding for 1 hour before and 2 hours after the levoFLOXacin dose. However, this still may not entirely avoid the interaction and may not always be feasible. LevoFLOXacin oral tablets may be taken without regard to food. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No therapeutic duplications were found for your selected drugs.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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