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Harvoni (ledipasvir / sofosbuvir) Drug Interactions

A total of 182 drugs are known to interact with Harvoni (ledipasvir / sofosbuvir).

  • 31 major drug interactions
  • 147 moderate drug interactions
  • 4 minor drug interactions

Show all medications in the database that may interact with Harvoni (ledipasvir / sofosbuvir).

Check for interactions with Harvoni (ledipasvir / sofosbuvir)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Harvoni (ledipasvir / sofosbuvir)

  • Adderall (amphetamine / dextroamphetamine)
  • Advil (ibuprofen)
  • Aleve (naproxen)
  • amlodipine (Norvasc)
  • amoxicillin (Amoxil, Trimox, Moxilin, Apo-Amoxi, Amoxicot, Moxatag, DisperMox, Wymox, Biomox)
  • Benadryl (diphenhydramine)
  • clonazepam (Klonopin, Klonopin Wafer)
  • furosemide (Lasix, Diaqua-2, Lo-Aqua)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • hydrochlorothiazide (HydroDIURIL, Microzide, Esidrix, Oretic, Diaqua, Aquazide H, Hydro Par, Ezide, Carozide, Loqua)
  • ibuprofen (Advil, Motrin, IBU, Proprinal, Advil Liqui-Gels, Motrin IB, IBU-200, Nuprin, Children's Motrin, Motrin Migraine Pain, Advil Migraine, Caldolor, Ibuprofen PMR, Advil Children's, Addaprin, NeoProfen, Advil Infant's Concentrated Drops, A-G Profen, Motrin Childrens, Childrens Ibuprofen Berry, Ibu-6, Ibu-8, Motrin Infant Drops, Ibu-Tab, Rufen, Genpril, Haltran, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • Klonopin (clonazepam)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Unithroid, Levothyrox, Euthyrox, Levo-T, L Thyroxine Roche, Eutroxsig, Novothyrox, Oroxine, Tirosint-Sol, Levotabs, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • melatonin (Melatonin Time Release, Bio-Melatonin, SGard, Health Aid Melatonin, VesPro Melatonin)
  • metformin (Glucophage, Glumetza, Glucophage XR, Riomet, Fortamet)
  • methadone (Methadose, Dolophine, Methadone Diskets, Methadose Sugar-Free)
  • metoprolol (Metoprolol Tartrate, Metoprolol Succinate ER, Lopressor, Toprol-XL, Kapspargo Sprinkle)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, Percolone, Oxyfast, Dazidox, RoxyBond, Oxecta, Oxydose, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol)
  • ranitidine (Zantac, Zantac 150, Zantac 75, Zantac 300, Deprizine, Zantac Injection, Acid Reducer, Zantac 25 mg EFFERdose, Berkley and Jensen Acid Reducer Maximum Strength, Zantac GELdose, Zantac 300 GELdose, Zantac EFFERdose, Acid Reducer Non-Prescription Strength, Acid Relief, Sunmark Acid Reducer Maximum Strength, Zantac 150 EFFERdose, Acid Control 75, Taladine, Careone Acid Reducer, Equaline Heartburn Relief, Acid Control 150)
  • ribavirin (Virazole, Ribasphere, Copegus, Rebetol, Moderiba, RibaTab, RibaPak)
  • Suboxone (buprenorphine / naloxone)
  • Synthroid (levothyroxine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Tramedo, Ultram ER, Larapam SR, GenRx Tramadol, ConZip, Zydol, Ryzolt, Tramahexal, Zamadol, Tramal SR, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Tylenol (acetaminophen)
  • Viagra (sildenafil)
  • Vitamin D3 (cholecalciferol)
  • Vitamins (multivitamin)
  • Xanax (alprazolam)

Harvoni (ledipasvir / sofosbuvir) disease interactions

There is 1 disease interaction with Harvoni (ledipasvir / sofosbuvir):

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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