Drug Interactions between Jaypirca and Revatio
This report displays the potential drug interactions for the following 2 drugs:
- Jaypirca (pirtobrutinib)
- Revatio (sildenafil)
Interactions between your drugs
sildenafil pirtobrutinib
Applies to: Revatio (sildenafil) and Jaypirca (pirtobrutinib)
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with weak inhibitors of CYP450 3A4 may increase the plasma concentrations of sildenafil, which is primarily metabolized by the isoenzyme. Pharmacokinetic models predict that this interaction may be more significant for oral rather than intravenous formulations of sildenafil, due at least partly to effects from first pass metabolism. An analysis of population pharmacokinetic data from clinical trials in adult pulmonary hypertension patients indicated a reduction in sildenafil clearance of approximately 30% when coadministered with mild CYP450 3A4 inhibitors. Sildenafil labeling does not currently report study data involving concurrent use with weak CYP450 3A4 inhibitors in pediatric pulmonary hypertension patients. Likewise, sildenafil products indicated for erectile dysfunction also focus on study data with more potent CYP450 3A4 inhibitors.
MANAGEMENT: Caution is advised if sildenafil is coadministered with weak CYP450 3A4 inhibitors. The significance of this interaction may be less for intravenous formulations of sildenafil and greater in patients with risk factors for adverse effects, such as those with renal impairment, hepatic impairment, and/or elderly patients. The presence of renal and/or hepatic dysfunction may necessitate adjustments of sildenafil's dose. If concurrent administration is necessary, patients should be monitored closely for adverse reactions and may benefit from initiating sildenafil at the lowest recommended dosage with slow, careful titration. Dosage adjustments may be necessary for sildenafil whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy based on efficacy and side effects. Patients should be advised to promptly notify their physician if they experience pain or tightness in the chest or jaw, irregular heartbeat, nausea, shortness of breath, visual disturbances, syncope, or prolonged erection (greater than 4 hours).
Drug and food interactions
pirtobrutinib food
Applies to: Jaypirca (pirtobrutinib)
Consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit should be avoided during treatment with pirtobrutinib as they may increase the blood levels of pirtobrutinib. This may increase the risk of side effects such as infection, bruising, bleeding, fatigue, muscle pain, diarrhea, swelling, and difficulty breathing. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
sildenafil food
Applies to: Revatio (sildenafil)
If you are receiving therapy with sildenafil you should avoid the regular consumption of large amounts of grapefruits and grapefruit juice. Grapefruit can raise the levels of sildenafil in your body and delay the time it takes for the medication to work. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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