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Drug Interactions between indomethacin and probenecid

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

probenecid indomethacin

Applies to: probenecid and indomethacin

MONITOR: Indomethacin clearance may be reduced during concomitant therapy with probenecid. The mechanism is unclear. Data from one study suggest that probenecid may interfere with biliary elimination of indomethacin. Other reports propose interference with the renal elimination of indomethacin. The risk of adverse effects may be increased.

MANAGEMENT: Patients receiving this combination should be monitored for increased NSAID side effects. Patients should be advised to report possible signs of NSAID toxicity such as dizziness, drowsiness, headache, tinnitus, nausea, vomiting, dyspepsia, abdominal pain, diarrhea, or black tarry stools. Dose reductions may be required.

References (6)
  1. Sinclair H, Gibson T (1986) "Interaction between probenecid and indomethacin." Br J Rheumatol, 25, p. 316-7
  2. Upton RA, Williams RL, Buskin JN, Jones RM (1982) "Effects of probenecid in ketoprofen kinetics." Clin Pharmacol Ther, 31, p. 705-12
  3. Runkel R, Mroszczak E, Chaplin M, et al. (1978) "Naproxen-probenecid interaction." Clin Pharmacol Ther, 24, p. 706-13
  4. Baber N, Halliday L, Sibeon R, et al. (1978) "The interaction between indomethacin and probenecid: a clinical and pharmacokinetic study." Clin Pharmacol Ther, 24, p. 298-307
  5. Skeith MD, Simkin PA, Healey LA (1968) "The renal excretion of indomethacin and its inhibition by probenecid." Clin Pharmacol Ther, 9, p. 89-93
  6. Mroszczak EJ, Combs DL, Goldblum R, et al. (1992) "The effect of probenecid on ketorolac pharmacokinetics after oral dosing of ketorolac tromethamine." Clin Pharmacol Ther, 51, p. 154

Drug and food interactions

Moderate

indomethacin food

Applies to: indomethacin

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References (1)
  1. (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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