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Drug interactions between Harvoni and Olysio

Results for the following 2 drugs:
Harvoni (ledipasvir/sofosbuvir)
Olysio (simeprevir)

Interactions between your drugs

Major

simeprevir ledipasvir

Applies to: Olysio (simeprevir) and Harvoni (ledipasvir / sofosbuvir)

Using simeprevir together with ledipasvir may significantly increase the blood levels of both medications, especially simeprevir. This may increase the risk of serious side effects such as skin rash and skin reactions to sunlight (photosensitivity), which may be severe enough to require hospitalization. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

simeprevir food

Applies to: Olysio (simeprevir)

Food significantly increases the absorption of simeprevir. You should take each dose of simeprevir with food. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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