Drug interactions between grapefruit and Plendil
| Results for the following 2 drugs:
Interactions between your drugs
There were no interactions found in our database between grapefruit and Plendil. However, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.
A total of 0 drugs are known to interact with grapefruit.
A total of 580 drugs (3357 brand and generic names) are known to interact with Plendil.
Drug and food interactions
Consumer information for this interaction is not currently available.
GENERALLY AVOID: The consumption of grapefruit juice may be associated with significantly increased plasma concentrations of some calcium channel blockers (CCBs) when they are administered orally. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. The interaction has been reported with the dihydropyridine CCBs (in roughly decreasing order of magnitude) felodipine, nisoldipine, nifedipine, and nimodipine, often with a high degree of interindividual variability. Grapefruit juice caused more than twofold increases in felodipine, nifedipine, and nisoldipine AUCs.
MANAGEMENT: The manufacturers of nifedipine and nisoldipine recommend avoiding grapefruit juice. Patients treated orally with other calcium channel blockers should be advised to avoid consumption of large amounts of grapefruits and grapefruit juice to prevent any undue fluctuations in serum drug levels. Increased effects on blood pressure may persist for up to 4 days after the consumption of grapefruit juice. Monitoring for calcium channel blocker adverse effects (e.g., headache, hypotension, syncope, tachycardia, edema) is recommended.
Therapeutic duplication warnings
No therapeutic duplications were found for your selected drugs.
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
||No information available.
Do not stop taking any medications without consulting your healthcare provider.
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