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Drug Interactions between fosphenytoin and tizanidine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

fosphenytoin tiZANidine

Applies to: fosphenytoin and tizanidine

MONITOR: One case report suggests elevated phenytoin levels associated with concomitant tizanidine use. The mechanism is unknown, but postulated to be competitive inhibition of hepatic enzymes. Drowsiness was the only adverse effect noted, and a dosage reduction of 20% was required. A similar interaction may occur with other hydantoins.

MANAGEMENT: Until further information is available close clinical and laboratory monitoring for toxicity is recommended. Dose adjustment may be necessary if an interaction is suspected. Patients should be advised to notify their physician if they experience symptoms of possible hydantoin toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia.

References (1)
  1. (2001) "Product Information. Zanaflex (tizanidine)." Acorda Therapeutics

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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