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Drug Interactions between fosphenytoin and mycophenolate mofetil

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

mycophenolate mofetil fosphenytoin

Applies to: mycophenolate mofetil and fosphenytoin

In vitro studies have shown that mycophenolic acid in concentrations up to 100 mcg/mL decreases protein binding of phenytoin from 90% to 87%. The clinical significance of this interaction is unknown. Decreased protein binding theoretically could lead to increased plasma phenytoin concentrations. However, clinical toxicity has not been reported. It may be appropriate to monitor more closely patients receiving phenytoin or other hydantoins with mycophenolic acid products.

References (1)
  1. (2001) "Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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