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Drug Interactions between fosphenytoin and isotretinoin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

ISOtretinoin fosphenytoin

Applies to: isotretinoin and fosphenytoin

MONITOR: Theoretical concerns exist that isotretinoin and phenytoin may have additive effects on bone loss. Decreased bone mineral density (osteomalacia, osteopenia, osteoporosis) and bone fractures have been reported with chronic use of either agent alone. However, no formal clinical trials have been conducted to evaluate whether there is an interactive effect on bone loss during coadministration. Isotretinoin did not alter the pharmacokinetics of phenytoin in a study of seven healthy volunteers.

MANAGEMENT: Caution is advised when isotretinoin and phenytoin are used together, particularly in patients with a history of osteomalacia, osteoporosis, or other disorders of bone metabolism. Bone-related laboratory and radiological tests should be considered.

References

  1. (2001) "Product Information. Dilantin (phenytoin)." Parke-Davis
  2. (2001) "Product Information. Accutane (isotretinoin)." Roche Laboratories

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Drug and food interactions

Moderate

ISOtretinoin food

Applies to: isotretinoin

GENERALLY AVOID: The combined use of ethanol and isotretinoin may result in a disulfiram-like reaction. The mechanism has not been established.

MANAGEMENT: Alcohol consumption should be avoided during isotretinoin therapy.

References

  1. (2001) "Product Information. Accutane (isotretinoin)." Roche Laboratories

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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