Drug interactions between fluoxetine and Synthroid
| Results for the following 2 drugs: |
|---|
| fluoxetine |
| Synthroid (levothyroxine) |
Interactions between your selected drugs
fluoxetine ↔ levothyroxine
Applies to:fluoxetine and Synthroid (levothyroxine)
Case reports suggest that thyroid hormone supplementation may enhance the therapeutic effects of fluoxetine in the treatment of major depression. The mechanism is unknown.
References
- Agid O, Shalev AY, Lerer B "Triiodothyronine augmentation of selective serotonin reuptake inhibitors in posttraumatic stress disorder." J Clin Psychiatry 62 (2001): 169-73
- Gupta S, Masand P, Tanquary JF "Thyroid hormone supplementation of fluoxetine in the treatment of major depression." Br J Psychiatry 159 (1991): 866-7
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2017 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
