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Drug Interactions between Fleet Enema and futibatinib

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

sodium phosphate futibatinib

Applies to: Fleet Enema (sodium biphosphate / sodium phosphate) and futibatinib

Using sodium phosphate together with futibatinib may increase the levels of phosphate in the blood, which may increase your risk of high phosphate levels (hyperphosphatemia), and a buildup of minerals such as calcium in different tissues in your body. Your doctor will check your blood phosphate level regularly when your first start treatment with futibatinib and regularly throughout treatment. They may recommend changes in your diet, phosphate-lowering therapy, and/or change your dose of futibatinib if necessary. Talk to your doctor if you have any questions or concerns. Contact your doctor as soon as possible if you develop signs and symptoms of high phosphate levels in the blood (hyperphosphatemia) such as muscle cramps, convulsions, tingling or numbness around the mouth, and bone pain. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

sodium biphosphate futibatinib

Applies to: Fleet Enema (sodium biphosphate / sodium phosphate) and futibatinib

Using sodium biphosphate together with futibatinib may increase the levels of phosphate in the blood, which may increase your risk of high phosphate levels (hyperphosphatemia), and a buildup of minerals such as calcium in different tissues in your body. Your doctor will check your blood phosphate level regularly when your first start treatment with futibatinib and regularly throughout treatment. They may recommend changes in your diet, phosphate-lowering therapy, and/or change your dose of futibatinib if necessary. Talk to your doctor if you have any questions or concerns. Contact your doctor as soon as possible if you develop signs and symptoms of high phosphate levels in the blood (hyperphosphatemia) such as muscle cramps, convulsions, tingling or numbness around the mouth, and bone pain. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Major

futibatinib food

Applies to: futibatinib

Grapefruit juice can increase the blood levels of futibatinib. This may increase side effects including dry or inflamed eyes, inflamed cornea, increased tears, disorder of the retina, high phosphate levels in your blood, redness, swelling, peeling or tenderness, mainly on the hands or feet, nails separating from the bed or poor formation of the nail, urinary tract infection, constipation, diarrhea, dry mouth, abdominal pain, fatigue, muscle and joint pain, decreased levels of blood cells (white blood cells, red blood cells, and platelets), and changes in liver function blood tests. You should avoid the consumption of grapefruit and grapefruit juice during treatment with futibatinib. Be sure to take the medication at approximately the same time every day to maintain consistent blood levels and effects. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

sodium biphosphate food

Applies to: Fleet Enema (sodium biphosphate / sodium phosphate)

Oral medications may not be properly absorbed when they are taken within one hour before starting sodium biphosphate for bowel cleansing. Talk to your doctor or pharmacist to see if you should adjust the dosing schedule of your other medications before you begin bowel cleansing treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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