Drug Interactions between finerenone and Lamprene
This report displays the potential drug interactions for the following 2 drugs:
- finerenone
- Lamprene (clofazimine)
Interactions between your drugs
clofazimine finerenone
Applies to: Lamprene (clofazimine) and finerenone
Consumer information for this interaction is not currently available.
MONITOR CLOSELY: Coadministration with moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of finerenone, which is primarily metabolized by CYP450 3A4 (90%) and to a minor extent by CYP450 2C8 (10%) to inactive metabolites. Drug interaction studies showed that concomitant use of finerenone with 500 mg thrice daily erythromycin, a moderate CYP450 3A4 inhibitor, increased mean finerenone peak plasma concentration (Cmax) and systemic exposure (AUC) by 88% and 248%, respectively. Verapamil, another moderate CYP450 3A4 inhibitor, given as a 240 mg controlled-release tablet once daily increased mean finerenone Cmax by 120% and AUC by 170%. High exposure to finerenone may potentiate the risk of hyperkalemia, and the risk may be further increased with decreasing kidney function and higher baseline potassium levels.
MANAGEMENT: Serum potassium and renal function should be monitored throughout treatment with finerenone, particularly during drug initiation or dosing change of either finerenone or the CYP450 3A4 inhibitor, and the finerenone dosage adjusted as appropriate in accordance with the product label. Patients should be advised to seek medical attention if they experience signs and symptoms of hyperkalemia such as nausea, vomiting, weakness, listlessness, tingling of the extremities, paralysis, confusion, weak pulse, and a slow or irregular heartbeat.
References
- Cerner Multum, Inc. "Australian Product Information."
- (2021) "Product Information. Kerendia (finerenone)." Bayer Pharmaceutical Inc
- (2022) "Product Information. Kerendia (finerenone)." Bayer Plc
Drug and food interactions
finerenone food
Applies to: finerenone
Finerenone may be taken with or without food. However, you should avoid grapefruit and grapefruit juice during treatment with this medication. Grapefruit juice may significantly increase the blood levels and effects of finerenone. This can increase the risk of developing hyperkalemia, or high levels of potassium in the blood, which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. You may be more likely to develop hyperkalemia during treatment with finerenone if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure. You should also avoid potassium-containing salt substitutes or over-the-counter potassium supplements during treatment with finerenone unless otherwise directed by your doctor. Seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, as these may be symptoms of hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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