Drug Interactions between febuxostat and Roszet
This report displays the potential drug interactions for the following 2 drugs:
- febuxostat
- Roszet (ezetimibe/rosuvastatin)
Interactions between your drugs
rosuvastatin febuxostat
Applies to: Roszet (ezetimibe / rosuvastatin) and febuxostat
Consumer information for this interaction is not currently available.
ADJUST DOSE: Coadministration with febuxostat may increase the plasma concentrations of rosuvastatin. The proposed mechanism is inhibition of breast cancer resistance protein (BCRP) efflux transporter in the gut wall by febuxostat, resulting in increased absorption and bioavailability of rosuvastatin. In ten healthy volunteers, administration of a single 10 mg dose of rosuvastatin following pretreatment with febuxostat 120 mg once daily for 4 days increased rosuvastatin peak plasma concentration (Cmax) and systemic exposure (AUC) on average by 2.1- and 1.9-fold, respectively, but had no effect on rosuvastatin half-life or renal clearance. High levels of HMG-CoA reductase inhibitory activity in plasma may be associated with an increased risk of musculoskeletal toxicity. Myopathy manifested as muscle pain and/or weakness associated with grossly elevated creatine kinase exceeding ten times the upper limit of normal has been reported occasionally. Rhabdomyolysis has also occurred rarely, which may be accompanied by acute renal failure secondary to myoglobinuria and may result in death.
MANAGEMENT: The dosage of rosuvastatin should start at 5 mg and not exceed 20 mg once daily when used in combination with febuxostat. Alternatively, a different statin that is not expected to be significantly affected by BCRP inhibition such as pitavastatin or pravastatin may be considered. All patients receiving statin therapy should be advised to promptly report any unexplained muscle pain, tenderness or weakness, particularly if accompanied by fever, malaise and/or dark colored urine. Therapy should be discontinued if creatine kinase is markedly elevated in the absence of strenuous exercise or if myopathy is otherwise suspected or diagnosed.
ezetimibe rosuvastatin
Applies to: Roszet (ezetimibe / rosuvastatin) and Roszet (ezetimibe / rosuvastatin)
Using ezetimibe together with rosuvastatin can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. In some cases, rhabdomyolysis can cause kidney damage and even death. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know immediately if you have unexplained muscle pain, tenderness, or weakness while taking these medications, especially if these symptoms are accompanied by fever or dark colored urine. You should also seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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