Drug Interactions between Excedrin and pneumococcal 21-valent conjugate vaccine
This report displays the potential drug interactions for the following 2 drugs:
- Excedrin (acetaminophen/aspirin/caffeine)
- pneumococcal 21-valent conjugate vaccine
Interactions between your drugs
acetaminophen pneumococcal 21-valent conjugate vaccine (cvx 327)
Applies to: Excedrin (acetaminophen / aspirin / caffeine) and pneumococcal 21-valent conjugate vaccine
Consumer information for this interaction is not currently available.
MONITOR: Acetaminophen (paracetamol) may reduce the immune response to pneumococcal vaccines in infants. A postmarketing clinical study using a vaccination schedule of 2, 3, 4, and 12 months of age suggests that acetaminophen administered at the same time or within the same day of vaccination may reduce the antibody response to the pneumococcal 13-valent conjugate vaccine after the infant series compared to controls that did not receive prophylactic acetaminophen. Responses to the booster (fourth) dose administered at 12 months were not affected. The clinical significance of this interaction is unclear.
MANAGEMENT: Caution is recommended if prophylactic acetaminophen is used concurrently or within the same day of infant pneumococcal vaccination.
aspirin caffeine
Applies to: Excedrin (acetaminophen / aspirin / caffeine) and Excedrin (acetaminophen / aspirin / caffeine)
Information for this minor interaction is available on the professional version.
Drug and food interactions
acetaminophen food
Applies to: Excedrin (acetaminophen / aspirin / caffeine)
Ask your doctor before using acetaminophen together with ethanol. This can cause serious side effects that affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
aspirin food
Applies to: Excedrin (acetaminophen / aspirin / caffeine)
Ask your doctor before using aspirin together with ethanol. Do not drink alcohol while taking aspirin. Alcohol can increase your risk of stomach bleeding caused by aspirin. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
caffeine food
Applies to: Excedrin (acetaminophen / aspirin / caffeine)
Information for this minor interaction is available on the professional version.
aspirin food
Applies to: Excedrin (acetaminophen / aspirin / caffeine)
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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