Skip to main content

Drug Interactions between everolimus and palbociclib

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

everolimus palbociclib

Applies to: everolimus and palbociclib

Palbociclib may increase the blood levels of everolimus. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if your condition changes or you experience new or worsening side effects of everolimus such as mouth ulcers, fever, infection, shortness of breath, diarrhea, dizziness, paleness, fainting, and/or unusual bleeding or bruising while taking these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

everolimus food

Applies to: everolimus

Grapefruit juice can increase the blood levels and effects of everolimus. You should not drink grapefruit juice or eat grapefruits during your treatment with everolimus. Orange juice is not expected to interact.

Moderate

palbociclib food

Applies to: palbociclib

Palbociclib oral capsules (Ibrance) should be taken with food to help with its absorption. Palbociclib oral tablets (Ibrance) may be taken with or without food. Do not consume grapefruit or grapefruit juice during treatment with palbociclib. Grapefruit and grapefruit juice can interact with palbociclib and increase the levels of palbociclib in your body. You may be more likely to experience side effects such as nausea; vomiting; diarrhea; loss of appetite; mouth sores; hair loss; weakness; pain, numbness, or tingling in the hands and feet; and impaired bone marrow function resulting in low numbers of different types of blood cells, which can increase the risk of anemia, bleeding problems, and infections. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer