Skip to main content

Drug Interactions between ethinyl estradiol / norelgestromin and mobocertinib

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Major

ethinyl estradiol mobocertinib

Applies to: ethinyl estradiol / norelgestromin and mobocertinib

Mobocertinib may reduce the blood levels of ethinyl estradiol, which may make it less reliable as a form of birth control. Alternative methods of birth control should be used during treatment with mobocertinib and for 1 month after stopping treatment to avoid unintended pregnancy. This is particularly important because mobocertinib may cause fetal harm. Talk to your gynecologist or other healthcare professional for help in selecting an effective method of birth control that is best for you. Men with female partners of reproductive potential receiving mobocertinib should use a condom during the treatment period and for 1 week after stopping treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Major

norelgestromin mobocertinib

Applies to: ethinyl estradiol / norelgestromin and mobocertinib

Mobocertinib may reduce the blood levels of norelgestromin, which may make it less reliable as a form of birth control. Alternative methods of birth control should be used during treatment with mobocertinib and for 1 month after stopping treatment to avoid unintended pregnancy. This is particularly important because mobocertinib may cause fetal harm. Talk to your gynecologist or other healthcare professional for help in selecting an effective method of birth control that is best for you. Men with female partners of reproductive potential receiving mobocertinib should use a condom during the treatment period and for 1 week after stopping treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Major

mobocertinib food

Applies to: mobocertinib

You should avoid consumption of grapefruit and grapefruit juice during treatment with mobocertinib. Grapefruit juice can increase the blood levels of mobocertinib. This may increase the risk of side effects such as diarrhea, nausea, vomiting, rash, fatigue, musculoskeletal pain, mouth sores and inflammation, heart failure, and rare but potentially serious and life-threatening irregular heart rhythm disorders. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

ethinyl estradiol food

Applies to: ethinyl estradiol / norelgestromin

Consumer information for this interaction is not currently available.

MONITOR: Coadministration of ethinyl estradiol may increase the plasma concentrations of drugs that are primarily metabolized by CYP450 1A2. In a study of 30 healthy volunteers administered the CYP450 1A2 substrate tizanidine, the systemic exposure (AUC) of tizanidine was 3.9 times greater in women using an oral contraceptive containing ethinyl estradiol.

MANAGEMENT: Patients should be monitored for increased adverse effects of the CYP450 1A2 substrate during concomitant use with ethinyl estradiol. Product labeling for the specific CYP450 1A2 substrate should be consulted for additional recommendations.

Minor

ethinyl estradiol food

Applies to: ethinyl estradiol / norelgestromin

Information for this minor interaction is available on the professional version.

Minor

ethinyl estradiol food

Applies to: ethinyl estradiol / norelgestromin

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


Report options

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.