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Vagifem (estradiol topical) Drug Interactions

A total of 249 drugs are known to interact with Vagifem (estradiol topical).

  • 9 major drug interactions
  • 220 moderate drug interactions
  • 20 minor drug interactions

Show all medications in the database that may interact with Vagifem (estradiol topical).

Check for interactions with Vagifem (estradiol topical)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Vagifem (estradiol topical)

  • amlodipine (Norvasc)
  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Aspir-Low, Bayer Aspirin, Ecotrin Adult Low Strength, Ascriptin, Fasprin, Arthritis Pain, Low Dose ASA, Aspiritab, Bufferin, Durlaza, Aspirin Lite Coat, Aspirtab, Halfprin, Bayer Children's Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Easprin, Aspergum, Buffered Aspirin, Ascriptin Enteric, Acuprin 81, Miniprin, Bayer Aspirin Regimen, St. Joseph 81 mg Chewable Aspirin, Empirin, Ecotrin Maximum Strength, St. Joseph Aspirin, Ecpirin, Bayer Women's Aspirin With Calcium, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspi-Cor, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Bayer Aspirin Extra Strength Plus, Buffex, Entercote, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Bufferin Extra Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, Zero-Order Release, YSP Aspirin, Migralex, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Aspirin Low Strength (aspirin)
  • Crestor (rosuvastatin)
  • Cymbalta (duloxetine)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Unithroid, Levothyrox, Euthyrox, Levo-T, L Thyroxine Roche, Eutroxsig, Novothyrox, Oroxine, Tirosint-Sol, Levotabs, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • metformin (Glucophage, Glumetza, Glucophage XR, Riomet, Fortamet)
  • Monistat (miconazole topical)
  • Nexium (esomeprazole)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • prednisone (Deltasone, Rayos, Sterapred DS, Sterapred, Prednicot, Meticorten, Liquid Pred, Orasone, Prednicen-M)
  • progesterone (Prometrium, Endometrin, Crinone, Cyclogest, Progest, Menopause Formula Progesterone, Prochieve, First Progesterone MC10, First Progesterone MC5, Gestone)
  • Replens (emollients topical)
  • simvastatin (Zocor, FloLipid)
  • Singulair (montelukast)
  • Synthroid (levothyroxine)
  • tamoxifen (Nolvadex, Tamoxen, Tamofen, Tamosin, Soltamox, Tamoxifen Hexal, Tamone, Emblon, Nolvadex D, Genox)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Tramedo, Ultram ER, Larapam SR, GenRx Tramadol, ConZip, Zydol, Ryzolt, Tramahexal, Zamadol, Tramal SR, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Yuvafem (estradiol topical)

Vagifem (estradiol topical) alcohol/food interactions

There are 2 alcohol/food interactions with Vagifem (estradiol topical)

Vagifem (estradiol topical) disease interactions

There are 17 disease interactions with Vagifem (estradiol topical) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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