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Vagifem (estradiol topical) Drug Interactions

A total of 249 drugs are known to interact with Vagifem (estradiol topical).

  • 9 major drug interactions
  • 220 moderate drug interactions
  • 20 minor drug interactions

Show all medications in the database that may interact with Vagifem (estradiol topical).

Check for interactions

Type in a drug name to check for interactions with Vagifem (estradiol topical).

Most frequently checked interactions

View interaction reports for Vagifem (estradiol topical) and the medicines listed below.

  • amlodipine (Norvasc)
  • aspirin (Aspir 81, Ecotrin, Aspirin Low Strength, Acetylsalicylic Acid, Bayer Aspirin, Aspir-Low, Bufferin, Ascriptin, Arthritis Pain, Aspiritab, Aspergum, Fasprin, Halfprin, Easprin, Ecotrin Adult Low Strength, Empirin, Migralex, Aspi-Cor, St. Joseph 81 mg Chewable Aspirin, Bayer Children's Aspirin, Buffered Aspirin, Durlaza, Ecotrin Maximum Strength, Entercote, Bufferin Extra Strength, Ascriptin Enteric, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspirtab, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Low Dose ASA, Bayer Aspirin Extra Strength Plus, Buffex, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, St. Joseph Aspirin, Stanback Analgesic, Norwich Aspirin, Acuprin 81, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Aspirin Lite Coat, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Aspirin Low Strength (aspirin)
  • Crestor (rosuvastatin)
  • Cymbalta (duloxetine)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Euthyrox, Unithroid, Levothyrox, Eutroxsig, Levo-T, Oroxine, L Thyroxine Roche, Levotabs, Novothyrox, Tirosint-Sol, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • metformin (Glucophage, Glumetza, Glucophage XR, Fortamet, Riomet)
  • Monistat (miconazole topical)
  • Nexium (esomeprazole)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Meticorten, Orasone, Liquid Pred, Prednicen-M)
  • progesterone (Prometrium, Crinone, Endometrin, Progest, Menopause Formula Progesterone, Cyclogest, Gestone, First Progesterone MC10, First Progesterone MC5, Prochieve)
  • Replens (emollients topical)
  • simvastatin (Zocor, FloLipid)
  • Singulair (montelukast)
  • Synthroid (levothyroxine)
  • tamoxifen (Nolvadex, Tamoxen, Tamosin, Soltamox, Tamofen, Tamoxifen Hexal, Tamone, Emblon, Nolvadex D, Genox)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, ConZip, Zydol, Tramal SR, GenRx Tramadol, Zamadol, Ryzolt, Tramedo, Larapam SR, Tramahexal SR, Tramahexal, Zydol XL, Rybix ODT, Ultram ODT)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Yuvafem (estradiol topical)

Vagifem (estradiol topical) alcohol/food interactions

There are 2 alcohol/food interactions with Vagifem (estradiol topical)

Vagifem (estradiol topical) disease interactions

There are 17 disease interactions with Vagifem (estradiol topical) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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