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Drug Interactions between Erleada and Sporanox

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

itraconazole apalutamide

Applies to: Sporanox (itraconazole) and Erleada (apalutamide)

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the oral bioavailability and plasma concentrations of itraconazole and ketoconazole. In vitro studies have shown that CYP450 3A4 is the major enzyme involved in their metabolism, and pharmacokinetic studies as well as case reports have demonstrated decreases in itraconazole and ketoconazole systemic exposure (AUC) by at least 80% and sometimes even to undetectable levels when coadministered with potent CYP450 3A4 inducers such as rifampin or phenytoin, including reports of treatment failure.

MANAGEMENT: Concomitant use of itraconazole or ketoconazole with potent CYP450 3A4 inducers should generally be avoided. Some authorities recommend avoiding coadministration of potent CYP450 3A4 inducers from 2 weeks before and during treatment with these azole antifungal agents unless the benefits outweigh the risk of potentially reduced antifungal efficacy. If coadministration is required, clinical response and antifungal activity should be closely monitored and the itraconazole or ketoconazole dosage increased as necessary.

Drug and food interactions

Moderate

itraconazole food

Applies to: Sporanox (itraconazole)

Food increases the absorption of itraconazole capsules but decreases the absorption of itraconazole oral solution. Capsules should be taken immediately after a full meal and the solution be taken on an empty stomach to ensure best results.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.