Drug Interactions between elacestrant and Lamprene
This report displays the potential drug interactions for the following 2 drugs:
- elacestrant
- Lamprene (clofazimine)
Interactions between your drugs
clofazimine elacestrant
Applies to: Lamprene (clofazimine) and elacestrant
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Coadministration with potent or moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of elacestrant, which is primarily metabolized by the isoenzyme. When elacestrant (172 mg once daily) was administered with itraconazole, a potent CYP450 3A4 inhibitor, elacestrant peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 4.4-fold and 5.3-fold, respectively. Concomitant use of fluconazole, a moderate CYP450 3A4 inhibitor, is predicted to increase elacestrant (345 mg single dose) Cmax and AUC by 1.6-fold and 2.3-fold, respectively. Increased exposure to elacestrant may increase the risk of adverse reactions such as musculoskeletal pain, nausea, dyslipidemia, increased liver enzymes, fatigue, decreased hemoglobin, and vomiting.
MANAGEMENT: Coadministration of elacestrant with potent or moderate CYP450 3A4 inhibitors should be avoided.
References
- (2023) "Product Information. Orserdu (elacestrant)." Stemline Therapeutics
Drug and food interactions
elacestrant food
Applies to: elacestrant
Elacestrant should be taken with food at approximately the same time each day. Grapefruit, grapefruit juice, and supplements that contain grapefruit, however, may increase the blood levels of elacestrant, which may increase the risk of side effects such as muscle pain, nausea, increased cholesterol, increased liver enzymes, fatigue, decreased hemoglobin, and vomiting. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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