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Drug interactions between doxorubicin and sorafenib

Results for the following 2 drugs:
doxorubicin
sorafenib

Interactions between your drugs

Moderate

DOXOrubicin SORAfenib

Applies to: doxorubicin and sorafenib

SORAfenib may increase the blood levels of DOXOrubicin. This may increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, mouth sores, heart problems, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to experience anemia, bleeding problems, or infections due to low blood cell counts. You should contact your doctor if you develop paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Also seek immediate medical attention if you experience signs and symptoms that may suggest heart problems such as coughing, difficulty breathing, fluid retention, swelling, chest pain, and irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

SORAfenib food

Applies to: sorafenib

You may experience reduced absorption of SORAfenib in the presence of food. Take SORAfenib on an empty stomach 1 hour before or 2 hours after a meal unless otherwise directed by your doctor. This will make it easier for your body to absorb the medication.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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