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Drug Interactions between doxepin topical and racepinephrine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

doxepin topical racepinephrine

Applies to: doxepin topical and racepinephrine

MONITOR: Concomitant use of beta-2 adrenergic agonists with tricyclic antidepressants (TCAs) may increase the risk and/or severity of cardiovascular adverse effects such as hypertension, palpitation, chest pain, and arrhythmia. In addition, both classes of drugs have been reported to produce electrocardiographic changes including flattening of the T wave and prolongation of the QTc interval, and these effects may be additive during coadministration.

MANAGEMENT: Caution is advised if beta-2 agonists are used with TCAs, or within two weeks of discontinuing the latter. Cardiovascular status should be closely monitored.

References (11)
  1. (2002) "Product Information. Proventil (albuterol)." Schering Corporation
  2. "Product Information. Serevent (salmeterol)." Glaxo Wellcome
  3. (2001) "Product Information. Maxair (pirbuterol)." 3M Pharmaceuticals
  4. (2001) "Product Information. Alupent (metaproterenol)." Boehringer-Ingelheim
  5. (2022) "Product Information. Tornalate (bitolterol)." Apothecon Inc
  6. (2001) "Product Information. Xopenex (levalbuterol)." Sepracor Inc
  7. (2001) "Product Information. Foradil (formoterol)." Novartis Pharmaceuticals
  8. (2006) "Product Information. Brovana (arformoterol)." Sepracor Inc
  9. (2011) "Product Information. Arcapta Neohaler (indacaterol)." Novartis Pharmaceuticals
  10. (2013) "Product Information. Breo Ellipta (fluticasone-vilanterol)." GlaxoSmithKline
  11. (2014) "Product Information. Striverdi Respimat (olodaterol)." Boehringer Ingelheim

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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