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Drug Interactions between doxacurium and piperacillin / tazobactam

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

piperacillin doxacurium

Applies to: piperacillin / tazobactam and doxacurium

MONITOR: Piperacillin may prolong the effects of nondepolarizing muscle relaxants. The mechanism is unknown, but small trials and case reports have provided data in support of an interaction between piperacillin and vecuronium. In contrast, a randomized controlled trial involving thirty patients undergoing abdominal operations reported no clinically important prolongation of vecuronium-induced muscle relaxation when piperacillin or cefoxitin was administered pre- or intra-operatively. The clinical significance and the extent to which other nondepolarizing muscle relaxants may interact remains unclear.

MANAGEMENT: Close observation for profound and prolonged respiratory depression and muscle weakness is recommended if these drugs must be used together.

References (8)
  1. Mackie K, Pavlin EG (1990) "Recurrent paralysis following piperacillin administration." Anesthesiology, 72, p. 561-3
  2. (2001) "Product Information. Zosyn (piperacillin-tazobactam)." Lederle Laboratories
  3. Condon RE, Munshi CA, Arfman RC (1995) "Interaction of vecuronium with piperacillin or cefoxitin evaluated in a prospective, randomized, double-blind clinical trial." Am Surg, 61, p. 403-6
  4. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  5. Cerner Multum, Inc. "Australian Product Information."
  6. Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
  7. Cerner Multum, Inc. (2015) "Canadian Product Information."
  8. Cerner Multum, Inc (2015) "ANVISA Bulário Eletrônico."

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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