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DPH (diphenhydramine) Drug Interactions

A total of 825 drugs are known to interact with DPH (diphenhydramine).

  • 33 major drug interactions
  • 788 moderate drug interactions
  • 4 minor drug interactions

Show all medications in the database that may interact with DPH (diphenhydramine).

Check for interactions with DPH (diphenhydramine)

Type in a drug name and select a drug from the list.

Common medications checked in combination with DPH (diphenhydramine)

  • Adderall (amphetamine / dextroamphetamine)
  • amlodipine (Norvasc)
  • caffeine (Vivarin, Alert, NoDoz, Caffedrine, Cafcit, Keep Going, Jet Alert Regular Strength, Jet Alert Double Strength, Jet Alert Maximum Strength, ConRx Alert, Pep-Back ReCharge, Pep-Back Peak Performance, Keep Alert, Stay Awake, Verv, Stat Awake, Stay Alert, NoDoz Maximum Strength, Wakespan, Lucidex, Diurex Maximum Relief Water Caps, Diurex Ultra, Pep-Back Ultra, 357 HR Magnum, Enerjets, Fastlene, Molie, Overtime, Valentine)
  • codeine
  • Cymbalta (duloxetine)
  • Demadex (torsemide)
  • DermOtic Oil (fluocinolone otic)
  • dextromethorphan (Delsym, Dextromethorphan HBr Adult Formula, Delsym 12 Hour Cough Relief, Cough Syrup DM, DexAlone, Bisolvon Dry, Buckleys Mixture, Robitussin CoughGels Long-Acting, Vicks Formula 44, Benylin DM, Calmylin, Strepsils Cough, Strepsils Cough Relief, Dry Cough, Hold, Robitussin 12-Hour Cough Relief, Pertussin ES, Babee Cof, Silphen DM, Pertussin DM, Vicks Formula 44 Custom Care Dry Cough Suppressant, Balminil DM, Delsym 12 Hour Cough Relief for Children & Adults, Novahistine DM, Covonia Bronchial Balsam, Robitussin Cough Long-Acting, Triaminic Thin Strips Long Acting Cough, Benadryl for the Family Dry Forte, Theraflu Thin Strips Cough, Neocitran Thin Strips Cough, Contac Cough, Robafen Cough Liquidgels, Jack & Jill Thin Strips Cough, Tussinol for Dry Coughs, Bisolvon Dry Junior, Dristan DM, Dexi-Tuss, Nucosef DM, Delsym Children's 12-Hour Cough Relief, Sucrets Cough, Pedia Relief, Triaminic Long Acting Cough, Creomulsion Children, Creomulsion, Buckley's DM, Buckley's Mixture Cough Suppressant, Tussin Cough Gels (Long Acting), Vicks Nature Fusion Cough, Duract Max Strength Cough, Scot-Tussin Diabetes, Lloydspharmacy Dry Adult Cough, 12 Hour Cough Relief, Triaminic Thin Strips Cough, ElixSure Cough, Scot-Tussin DM Cough Chasers, Hold DM, Pertussin CS Childrens, Robitussin Children's Cough Long-Acting, St. Joseph Cough Suppressant, PediaCare Children's Long-Acting Cough, Tussin Pediatric, Robafen Pediatric Cough & Cold, Vicks Dayquil Cough)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Unisom SleepGels, Diphenhist, Sleep, Dicopanol, Diphenadryl, Sominex, Diphen, Diphedryl, Hydramine, Allermax, Nytol, Benadryl Children's Allergy, Diphenydramine Quick Melt, Pharbedryl, Buckley's Bedtime, Hyrexin, Diphen Cough, DPH, Allergia-C, Q-Dryl, Sleep-Eze-3, Valu-Dryl, Diphenyl, Beldin, Sleep-ettes, Diphendryl, Q-Dryl A/F, Tranquil Nighttime Sleep Aid, Dormin, Sleepwell 2-nite, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Hydramine Cough Syrup, Bydramine, 40 Winks, Diphen AF, Aler-Dryl, Benahist-10, Benahist-50, Benoject-50, Calm-Aid, Genahist, Alka-Seltzer Plus Allergy, Aller-G-Time, Sleep Tab II, Sleep Tabs, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Altaryl, Triaminic Thin Strips Cough & Runny Nose, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Quenalin, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Histaprin, Z-Sleep, Unisom SleepMelts, PediaCare Children's Allergy, Truxadryl, Simply Sleep, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • diphenhydramine / ibuprofen (Ibuprofen PM, Advil PM, Motrin PM)
  • diphenhydramine / phenylephrine (Delsym Children's Night Time Cough & Cold, PediaCare Nighttime Multi-Symptom Cold, Sudafed PE Nighttime Nasal Decongestant, Diphentann-D, Uni-Tann D, Aldex-CT, Diphenmax D, Triaminic Thin Strips Night Time Cold & Cough, Dimetapp Children's Nighttime Cold & Congestion, Children's Triacting Night Time, Triaminic Night Time Cold & Cough, Theraflu Thin Strips Nighttime Cold and Cough, Benadryl Children's Allergy Plus Congestion, Robitussin Night Time Cough & Cold, Alahist LQ, Dytan-D, Pediatex-CT, D-Tann, Benadryl-D Allergy Plus Sinus, Benadryl-D Children's Allergy & Sinus, PediaCare Children's Allergy & Cold)
  • diphenhydramine / pseudoephedrine (Tekral, Benylin Multi-Symptom, Actifed Allergy Day/Night, Tavist NightTime Allergy, Benadryl Children's Allergy And Sinus, Benadryl Allergy Sinus, Respa SA, Benaphen Plus)
  • Dostinex (cabergoline)
  • ethinyl estradiol / levonorgestrel (Aviane, Alesse, Lutera, Levora, Seasonique, Portia, Aubra, Camrese, Vienva, Lessina, Levlen, Ashlyna, Jolessa, Altavera, Kurvelo, Larissia, Lillow, Falmina, Seasonale, Trivora, Sronyx, Chateal, Amethia, Levlite, Marlissa, Amethyst, Introvale, Fayosim, Alesse-28, Orsythia, Lybrel, Quartette, Daysee, Balcoltra, Amethia Lo, Quasense, CamreseLo, Ayuna, Levonest, Nordette, Triphasil, LoSeasonique, Nordette-21, Nordette-28, Enpresse, Myzilra, Setlakin, Rivelsa, Simpesse, Lo Simpesse, Jaimiess, Afirmelle, Elifemme, Tri-Levlen, Triphasil-21, Triphasil-28, Alesse-21, Preven EC, Triquilar 21, Triquilar 28, Min-Ovral 21, Min-Ovral 28, Delyla, Iclevia, Aubra EQ, Chateal EQ)
  • Euthyrox (levothyroxine)
  • hydrocodone (Hysingla ER, Zohydro ER, Vantrela ER)
  • Klonopin (clonazepam)
  • Lacrisert (ocular lubricant ophthalmic)
  • Levothyrox (levothyroxine)
  • Lexapro (escitalopram)
  • Lithium Carbonate ER (lithium)
  • melatonin (Melatonin Time Release, Bio-Melatonin, SGard, Health Aid Melatonin, VesPro Melatonin)
  • Norvasc (amlodipine)
  • Plaquenil (hydroxychloroquine)
  • potassium chloride (Klor-Con, KCl, K-Dur, Klor-Con M20, K-Tab, Klor-Con M10, Micro-K, Kay Ciel, Klor-Con 10, K-Dur 20, Slow-K, K-Lor, Klor-Con Sprinkle, Klotrix, Micro-K 10, Cena K, Klor-Con 8, K-Dur 10, Epiklor, Kaochlor, Kaon-CI, K-Norm, Kal Potassium 99, Kaochlor S-F, Kaon-CL 20%, K-Sol, K + Potassium, Klor-Con/25, K-8, K-10, Glu-K, Kaon-CL 10, Kato, Ed K+10, PC-10, Ten-K, Klor-Con M15, K-Vescent (Potassium Chloride), K+Care, Klorvess, Rum-K, Gen-K)
  • primidone (Mysoline)
  • Toradol (ketorolac)
  • Wellbutrin XL (bupropion)
  • Xanax (alprazolam)
  • Zanaflex (tizanidine)
  • Zofran (ondansetron)

DPH (diphenhydramine) alcohol/food interactions

There is 1 alcohol/food interaction with DPH (diphenhydramine)

DPH (diphenhydramine) disease interactions

There are 8 disease interactions with DPH (diphenhydramine) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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