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Zipsor (diclofenac) Drug Interactions

A total of 496 drugs are known to interact with Zipsor (diclofenac).

  • 86 major drug interactions
  • 374 moderate drug interactions
  • 36 minor drug interactions

Show all medications in the database that may interact with Zipsor (diclofenac).

Check for interactions

Type in a drug name to check for interactions with Zipsor (diclofenac).

Most frequently checked interactions

View interaction reports for Zipsor (diclofenac) and the medicines listed below.

  • Aleve (naproxen)
  • Ambien (zolpidem)
  • aspirin (Aspir 81, Ecotrin, Aspirin Low Strength, Acetylsalicylic Acid, Bayer Aspirin, Aspir-Low, Bufferin, Ascriptin, Arthritis Pain, Aspiritab, Aspergum, Fasprin, Halfprin, Easprin, Ecotrin Adult Low Strength, Empirin, Migralex, Aspi-Cor, St. Joseph 81 mg Chewable Aspirin, Bayer Children's Aspirin, Buffered Aspirin, Durlaza, Ecotrin Maximum Strength, Entercote, Bufferin Extra Strength, Ascriptin Enteric, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspirtab, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Low Dose ASA, Bayer Aspirin Extra Strength Plus, Buffex, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, St. Joseph Aspirin, Stanback Analgesic, Norwich Aspirin, Acuprin 81, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Aspirin Lite Coat, Heartline, Bayer Advanced Aspirin, Buffasal)
  • baclofen (Lioresal, Gablofen, Kemstro, Lioresal Intrathecal)
  • cyclobenzaprine (Flexeril, Amrix, Fexmid, Comfort Pac with Cyclobenzaprine)
  • Cymbalta (duloxetine)
  • Flexeril (cyclobenzaprine)
  • Flonase (fluticasone nasal)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • hydrocodone (Hysingla ER, Zohydro ER, Vantrela ER)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • Lyrica (pregabalin)
  • metformin (Glucophage, Glumetza, Glucophage XR, Fortamet, Riomet)
  • naproxen (Aleve, Naprosyn, Anaprox, Naproxen Sodium DS, EC-Naprosyn, Anaprox-DS, Naprelan, Comfort Pac with Naproxen, Leader Naproxen Sodium, Aflaxen, Midol Extended Relief, Flanax Pain Reliever, Pamprin All Day Relief, All Day Pain Relief, All Day Relief)
  • Norco (acetaminophen / hydrocodone)
  • Synthroid (levothyroxine)
  • tizanidine (Zanaflex)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, ConZip, Zydol, Tramal SR, GenRx Tramadol, Zamadol, Ryzolt, Tramedo, Larapam SR, Tramahexal SR, Tramahexal, Zydol XL, Rybix ODT, Ultram ODT)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Tylenol (acetaminophen)
  • venlafaxine (Effexor, Effexor XR)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)

Zipsor (diclofenac) alcohol/food interactions

There are 3 alcohol/food interactions with Zipsor (diclofenac)

Zipsor (diclofenac) disease interactions

There are 13 disease interactions with Zipsor (diclofenac) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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