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Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine) Drug Interactions

A total of 837 drugs are known to interact with Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine).

  • 168 major drug interactions
  • 656 moderate drug interactions
  • 13 minor drug interactions

Show all medications in the database that may interact with Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine).

Check for interactions with Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine)

  • benzonatate (Tessalon Perles, Tessalon, Zonatuss)
  • bupivacaine (Marcaine, Sensorcaine, Sensorcaine-MPF, Sensorcaine-MPF Spinal, Marcaine HCl, Marcaine Spinal)
  • Calcium Concentrate (calcium carbonate)
  • dexamethasone (Decadron, Dexamethasone Intensol, Dexasone, Decadron Phosphate, Injectable, Hexadrol, Zonacort, Decadron-LA, Dexacen-4, LoCort, Adrenocot LA, TaperDex, Dalalone, Dalalone DP, Dalalone LA, Decaject, Decaject LA, Zema Pak, Baycadron, Dexacort Phosphate in Respihaler, Solurex LA, Solurex, Adrenocot, De-Sone LA, Dexacort-LA, Dexasone LA, Dexone, Dexone LA, Primethasone, ZoDex, Dexacorten, Medidex, Medidex LA, Dexpak Taperpak)
  • Dextrose (glucose)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Unisom SleepGels, Diphenhist, Sleep, Dicopanol, Diphenadryl, Sominex, Diphen, Diphedryl, Hydramine, Allermax, Nytol, Benadryl Children's Allergy, Diphenydramine Quick Melt, Pharbedryl, Buckley's Bedtime, Hyrexin, Diphen Cough, DPH, Allergia-C, Q-Dryl, Sleep-Eze-3, Valu-Dryl, Diphenyl, Beldin, Sleep-ettes, Diphendryl, Q-Dryl A/F, Tranquil Nighttime Sleep Aid, Dormin, Sleepwell 2-nite, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Hydramine Cough Syrup, Bydramine, 40 Winks, Diphen AF, Aler-Dryl, Benahist-10, Benahist-50, Benoject-50, Calm-Aid, Genahist, Alka-Seltzer Plus Allergy, Aller-G-Time, Sleep Tab II, Sleep Tabs, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Altaryl, Triaminic Thin Strips Cough & Runny Nose, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Quenalin, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Histaprin, Z-Sleep, Unisom SleepMelts, PediaCare Children's Allergy, Truxadryl, Simply Sleep, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • epinephrine (EpiPen, Adrenalin, Auvi-Q, EpiPen 2-Pak, EpiPen Auto-Injector, Adrenaclick, EpiPen JR 2-Pak, EpiPen Jr, Symjepi, Bronitin, Primatene Mist, Twinject, Asthmahaler, Adrenalin Chloride, Ana-Guard, Sus-Phrine Injection, EpiPen JR Auto-Injector, Bronchial Mist with Pump, Epi EZ Pen, Medihaler-Epi, Bronkaid Mist, EPIsnap)
  • famotidine (Pepcid, Pepcid AC, Acid Reducer-Famotidine, Acid Control, Heartburn Relief, Pepcid AC Maximum Strength, Pepcid AC Chewable Tablets, Pepcid Oral Suspension, Acid Reducer Original Strength, Acid Reducer Maximum Strength, Heartburn Relief Maximum Strength, Acid Controller Original Strength, Fluxid, Pepcid RPD, Mylanta AR, Pepcid AC Maximum Strength Tablets, Acid Controller Maximum Strength)
  • Flovent (fluticasone)
  • Kenalog-40 (triamcinolone)
  • lidocaine (DentiPatch, Xylocaine-MPF, Lidoject 1, Xylocaine HCl, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, UAD Caine, Anestacaine)
  • loperamide (Imodium, Imodium A-D, Anti-Diarrheal, Imotil, Kaopectate II, Neo-Diaral, Pepto Diarrhea Control, Kao-Paverin, Diar-Aid, Diamode, Up and Up Anti-Diarrheal Solution, Kaopectate 1-D, A-D Anti-Diarrheal)
  • Medrol (methylprednisolone)
  • miconazole (Oravig)
  • pantoprazole (Protonix, Protonix IV)
  • Pseudoephedrine Sinus (acetaminophen / pseudoephedrine)
  • sulfamethoxazole (Gantanol)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Tramedo, Ultram ER, Larapam SR, GenRx Tramadol, ConZip, Zydol, Ryzolt, Tramahexal, Zamadol, Tramal SR, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
  • zolpidem (Ambien, Ambien CR, Zolpimist, Intermezzo, Edluar)

Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine) alcohol/food interactions

There is 1 alcohol/food interaction with Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine)

Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine) disease interactions

There are 7 disease interactions with Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine) which include:

More about Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine)

Related treatment guides

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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