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Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine) Drug Interactions

A total of 837 drugs are known to interact with Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine).

  • 168 major drug interactions
  • 656 moderate drug interactions
  • 13 minor drug interactions

Show all medications in the database that may interact with Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine).

Check for interactions

Type in a drug name to check for interactions with Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine).

Most frequently checked interactions

View interaction reports for Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine) and the medicines listed below.

  • benzonatate (Tessalon Perles, Tessalon, Zonatuss)
  • bupivacaine (Marcaine, Sensorcaine, Marcaine Spinal, Sensorcaine-MPF Spinal, Marcaine HCl, Sensorcaine-MPF)
  • Calcium Concentrate (calcium carbonate)
  • dexamethasone (Decadron, Dexamethasone Intensol, Decadron Phosphate, Injectable, Hexadrol, Dexasone, TaperDex, Baycadron, Dexacort Phosphate in Respihaler, Dexone, Dexone LA, ZoDex, Dexpak Taperpak, Zonacort, LoCort, Adrenocot LA, Dalalone, Dalalone DP, Dalalone LA, HiDex, Decaject, Decaject LA, Zema Pak, Decadron-LA, Solurex LA, Dexacen-4, Solurex, Adrenocot, De-Sone LA, Dexacort-LA, Dexasone LA, Primethasone, Dexacorten, Medidex, Medidex LA)
  • Dextrose (glucose)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Sleep, Unisom SleepGels, Sominex, Sleep Tabs, Benadryl Children's Allergy, Dicopanol, Diphen, Nytol, Simply Sleep, Diphenhist, Hydramine, Diphenydramine Quick Melt, Sleepwell 2-nite, Hydramine Cough Syrup, Bydramine, Diphedryl, DPH, Calm-Aid, Diphenadryl, Sleep Tab II, Diphenyl, Altaryl, Quenalin, Diphendryl, Sleep-ettes D, Dytan, Vanamine PD, Unisom SleepMelts, Dormin, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Buckley's Bedtime, Hyrexin, 40 Winks, Diphen AF, Diphen Cough, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Genahist, Alka-Seltzer Plus Allergy, Q-Dryl, Aller-G-Time, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Uni-Tann, Q-Dryl A/F, Diphenmax, Nightime Sleepaid, Ben-Tann, Pharbedryl, Histaprin, Z-Sleep, Tranquil Nighttime Sleep Aid, PediaCare Children's Allergy, Truxadryl, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • epinephrine (EpiPen, Adrenalin, EpiPen 2-Pak, Primatene Mist, Auvi-Q, EpiPen JR 2-Pak, Asthmahaler, EpiPen Auto-Injector, Adrenaclick, EpiPen Jr, Twinject, Adrenalin Chloride, Medihaler-Epi, Symjepi, EPIsnap, Ana-Guard, Sus-Phrine Injection, EpiPen JR Auto-Injector, Bronitin, Bronchial Mist with Pump, Epi EZ Pen, Bronkaid Mist)
  • famotidine (Pepcid, Pepcid AC, Acid Reducer-Famotidine, Heartburn Relief, Pepcid AC Maximum Strength, Pepcid AC Chewable Tablets, Pepcid Oral Suspension, Fluxid, Acid Control, Acid Reducer Original Strength, Acid Reducer Maximum Strength, Heartburn Relief Maximum Strength, Acid Controller Original Strength, Pepcid RPD, Mylanta AR, Pepcid AC Maximum Strength Tablets, Acid Controller Maximum Strength)
  • Flovent (fluticasone)
  • Kenalog-40 (triamcinolone)
  • lidocaine (Xylocaine-MPF, Xylocaine HCl, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, UAD Caine, Anestacaine, DentiPatch)
  • loperamide (Imodium, Imodium A-D, Anti-Diarrheal, Pepto Diarrhea Control, Diamode, Kaopectate II, Neo-Diaral, Imotil, Kao-Paverin, Diar-Aid, Up and Up Anti-Diarrheal Solution, Kaopectate 1-D, A-D Anti-Diarrheal)
  • Medrol (methylprednisolone)
  • miconazole (Oravig)
  • pantoprazole (Protonix, Protonix IV)
  • Pseudoephedrine Sinus (acetaminophen / pseudoephedrine)
  • sulfamethoxazole (Gantanol)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, ConZip, Zydol, Tramal SR, GenRx Tramadol, Zamadol, Ryzolt, Tramedo, Larapam SR, Tramahexal SR, Tramahexal, Zydol XL, Rybix ODT, Ultram ODT)
  • zolpidem (Ambien, Ambien CR, Zolpimist, Intermezzo, Edluar)

Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine) alcohol/food interactions

There is 1 alcohol/food interaction with Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine)

Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine) disease interactions

There are 7 disease interactions with Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine) which include:

More about Z-COF 12 (dextromethorphan / guaifenesin / pseudoephedrine)

Related treatment guides

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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