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Drug Interactions between dexchlorpheniramine / dextromethorphan / phenylephrine / pyrilamine and ifosfamide / mesna

This report displays the potential drug interactions for the following 2 drugs:

  • dexchlorpheniramine/dextromethorphan/phenylephrine/pyrilamine
  • ifosfamide/mesna

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Interactions between your drugs

Moderate

ifosfamide pyrilamine

Applies to: ifosfamide / mesna and dexchlorpheniramine / dextromethorphan / phenylephrine / pyrilamine

Ifosfamide may cause central nervous system side effects such as drowsiness, confusion, hallucinations, blurred vision, abnormal behavior, abnormal muscle movements, seizures, and even coma in some cases. Combining it with other medications that can also affect the nervous system such as pyrilamine may increase the risk and/or severity of these effects. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

ifosfamide dexchlorpheniramine

Applies to: ifosfamide / mesna and dexchlorpheniramine / dextromethorphan / phenylephrine / pyrilamine

Ifosfamide may cause central nervous system side effects such as drowsiness, confusion, hallucinations, blurred vision, abnormal behavior, abnormal muscle movements, seizures, and even coma in some cases. Combining it with other medications that can also affect the nervous system such as dexchlorpheniramine may increase the risk and/or severity of these effects. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

pyrilamine food

Applies to: dexchlorpheniramine / dextromethorphan / phenylephrine / pyrilamine

Alcohol can increase the nervous system side effects of pyrilamine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with pyrilamine. Do not use more than the recommended dose of pyrilamine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

dexchlorpheniramine food

Applies to: dexchlorpheniramine / dextromethorphan / phenylephrine / pyrilamine

Alcohol can increase the nervous system side effects of dexchlorpheniramine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with dexchlorpheniramine. Do not use more than the recommended dose of dexchlorpheniramine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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