Skip to main content

Drug Interactions between Depakote and Tydemy

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

ethinyl estradiol divalproex sodium

Applies to: Tydemy (drospirenone / ethinyl estradiol / levomefolate calcium) and Depakote (divalproex sodium)

Using ethinyl estradiol together with divalproex sodium can cause loss of seizure control or symptoms such as tremors, poor muscle coordination, increased seizures, and changes in behavior. Talk with your doctor before using these medications together, and report any side effects promptly. You may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

divalproex sodium drospirenone

Applies to: Depakote (divalproex sodium) and Tydemy (drospirenone / ethinyl estradiol / levomefolate calcium)

Using drospirenone together with divalproex sodium can cause loss of seizure control or symptoms such as tremors, poor muscle coordination, increased seizures, and changes in behavior. Talk with your doctor before using these medications together, and report any side effects promptly. You may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

divalproex sodium levomefolate calcium

Applies to: Depakote (divalproex sodium) and Tydemy (drospirenone / ethinyl estradiol / levomefolate calcium)

Some anticonvulsant medications may reduce the blood levels of folic acid. In addition, folic acid treatment may reduce the blood levels of certain anticonvulsants. Talk to your doctor if you have any questions or concerns. You may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if your condition changes or you experience loss of seizure control. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Drug and food interactions

Moderate

divalproex sodium food

Applies to: Depakote (divalproex sodium)

Alcohol can increase the nervous system side effects of divalproex sodium such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with divalproex sodium. Do not use more than the recommended dose of divalproex sodium, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Switch to professional interaction data

Moderate

drospirenone food

Applies to: Tydemy (drospirenone / ethinyl estradiol / levomefolate calcium)

Grapefruit juice may increase the blood levels of certain medications such as drospirenone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with drospirenone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

Switch to professional interaction data

Minor

ethinyl estradiol food

Applies to: Tydemy (drospirenone / ethinyl estradiol / levomefolate calcium)

Information for this minor interaction is available on the professional version.

Minor

ethinyl estradiol food

Applies to: Tydemy (drospirenone / ethinyl estradiol / levomefolate calcium)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.