Drug Interactions between Denzapine and Stalevo 100
This report displays the potential drug interactions for the following 2 drugs:
- Denzapine (clozapine)
- Stalevo 100 (carbidopa/entacapone/levodopa)
Interactions between your drugs
cloZAPine levodopa
Applies to: Denzapine (clozapine) and Stalevo 100 (carbidopa / entacapone / levodopa)
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Agents with antidopaminergic activity such as quetiapine and clozapine may antagonize the pharmacologic effects of dopaminergic drugs, and vice versa. Quetiapine and clozapine may cause extrapyramidal reactions (i.e., acute dystonic reactions, tardive dyskinesia, akathisia, Parkinson-like symptoms) due to antidopaminergic effects. In addition, the central nervous system depressant and hypotensive effects of these agents may be additively or synergistically increased when taken together. However, some authorities have approved the use of clozapine in patients with psychosis in Parkinson's disease (PD) when other treatment strategies have failed (UK), and quetiapine is considered as possibly effective in the treatment of psychosis in PD patients by several authorities, although this remains an off-label use.
MANAGEMENT: Concomitant use of dopaminergic drugs with antidopaminergic agents such as clozapine or quetiapine should generally be avoided. Patients should be alerted to the possibility of excessive drowsiness and monitored for potentially diminished therapeutic response to both treatments. Patients treated for PD should generally avoid antidopaminergic agents, since these agents may cause extrapyramidal reactions and exacerbate the symptoms of PD. Consult the manufacturer's labeling and local guidelines for specific recommendations. When treatment for neuroleptic-induced extrapyramidal symptoms is required, anticholinergic anti-parkinsonian agents should be used in preference to levodopa. Likewise, patients with a major psychotic disorder should ordinarily not be treated with dopaminergic drugs because of the risk of exacerbating the psychosis with an increase in central dopaminergic tone.
cloZAPine entacapone
Applies to: Denzapine (clozapine) and Stalevo 100 (carbidopa / entacapone / levodopa)
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Agents with antidopaminergic activity such as quetiapine and clozapine may antagonize the pharmacologic effects of dopaminergic drugs, and vice versa. Quetiapine and clozapine may cause extrapyramidal reactions (i.e., acute dystonic reactions, tardive dyskinesia, akathisia, Parkinson-like symptoms) due to antidopaminergic effects. In addition, the central nervous system depressant and hypotensive effects of these agents may be additively or synergistically increased when taken together. However, some authorities have approved the use of clozapine in patients with psychosis in Parkinson's disease (PD) when other treatment strategies have failed (UK), and quetiapine is considered as possibly effective in the treatment of psychosis in PD patients by several authorities, although this remains an off-label use.
MANAGEMENT: Concomitant use of dopaminergic drugs with antidopaminergic agents such as clozapine or quetiapine should generally be avoided. Patients should be alerted to the possibility of excessive drowsiness and monitored for potentially diminished therapeutic response to both treatments. Patients treated for PD should generally avoid antidopaminergic agents, since these agents may cause extrapyramidal reactions and exacerbate the symptoms of PD. Consult the manufacturer's labeling and local guidelines for specific recommendations. When treatment for neuroleptic-induced extrapyramidal symptoms is required, anticholinergic anti-parkinsonian agents should be used in preference to levodopa. Likewise, patients with a major psychotic disorder should ordinarily not be treated with dopaminergic drugs because of the risk of exacerbating the psychosis with an increase in central dopaminergic tone.
levodopa entacapone
Applies to: Stalevo 100 (carbidopa / entacapone / levodopa) and Stalevo 100 (carbidopa / entacapone / levodopa)
The side effects of levodopa may be increased when it is used in combination with entacapone. You may need a dose adjustment if you have been taking levodopa and are starting or stopping treatment with entacapone. Contact your doctor if your condition changes or if you experience movement difficulties, increased drowsiness, dizziness, lightheadedness, flushing, and/or fainting. Avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
cloZAPine food
Applies to: Denzapine (clozapine)
Alcohol can increase the nervous system side effects of cloZAPine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cloZAPine. Do not use more than the recommended dose of cloZAPine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
levodopa food
Applies to: Stalevo 100 (carbidopa / entacapone / levodopa)
Alcohol can increase the nervous system side effects of levodopa such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with levodopa. You may experience reduced effectiveness of levodopa in the presence of foods or enteral (tube) feedings with a high protein content. This may make the symptoms of Parkinson's disease worse. Talk with your doctor or nutrition counselor about the best foods to eat while you are taking this medication. Contact your doctor if your condition changes.
entacapone food
Applies to: Stalevo 100 (carbidopa / entacapone / levodopa)
Alcohol can increase the nervous system side effects of entacapone such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with entacapone. Do not use more than the recommended dose of entacapone, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
levodopa food
Applies to: Stalevo 100 (carbidopa / entacapone / levodopa)
Levodopa and multivitamin with minerals should not be taken orally at the same time. Products that contain iron may interfere with the absorption of levodopa and reduce its effectiveness. You should separate the dosing of these medications by as much as possible. Contact your doctor if your Parkinson symptoms worsen. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
cloZAPine food
Applies to: Denzapine (clozapine)
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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