Drug Interactions between dasabuvir / ombitasvir / paritaprevir / ritonavir and nirmatrelvir / ritonavir
This report displays the potential drug interactions for the following 2 drugs:
- dasabuvir/ombitasvir/paritaprevir/ritonavir
- nirmatrelvir/ritonavir
Interactions between your drugs
paritaprevir nirmatrelvir
Applies to: dasabuvir / ombitasvir / paritaprevir / ritonavir and nirmatrelvir / ritonavir
Using nirmatrelvir/ritonavir (Paxlovid) together with dasabuvir/ombitasvir/paritaprevir/ritonavir (Viekira Pak) may increase the blood levels of some of the active drug components in both medications. In general, it is recommended that you continue with your hepatitis C virus treatment regimen as previously prescribed during therapy with Paxlovid. However, you should let your doctor know if you experience increased side effects. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
ritonavir food
Applies to: dasabuvir / ombitasvir / paritaprevir / ritonavir and nirmatrelvir / ritonavir
Ritonavir should be taken with food to lessen gastrointestinal side effects. It is important that you take this medication exactly as prescribed by your doctor. Do not change your treatment or stop treatment without first talking to your doctor.
paritaprevir food
Applies to: dasabuvir / ombitasvir / paritaprevir / ritonavir
Food significantly increases the absorption of paritaprevir. You should take each dose of paritaprevir with a meal. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Protease inhibitors
Therapeutic duplication
The recommended maximum number of medicines in the 'protease inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'protease inhibitors' category:
- dasabuvir/ombitasvir/paritaprevir/ritonavir
- nirmatrelvir/ritonavir
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Antiviral boosters
Therapeutic duplication
The recommended maximum number of medicines in the 'antiviral boosters' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'antiviral boosters' category:
- dasabuvir/ombitasvir/paritaprevir/ritonavir
- nirmatrelvir/ritonavir
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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