Drug Interactions between Corlanor and Pfizerpen
This report displays the potential drug interactions for the following 2 drugs:
- Corlanor (ivabradine)
- Pfizerpen (penicillin g potassium)
Interactions between your drugs
No interactions were found between Corlanor and Pfizerpen. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Corlanor
A total of 419 drugs are known to interact with Corlanor.
- Corlanor is in the drug class miscellaneous cardiovascular agents.
- Corlanor is used to treat Heart Failure.
Pfizerpen
A total of 50 drugs are known to interact with Pfizerpen.
- Pfizerpen is in the drug class natural penicillins.
-
Pfizerpen is used to treat the following conditions:
- Actinomycosis
- Anthrax
- Aspiration Pneumonia
- Bacteremia
- Bacterial Infection
- Botulism
- Clostridioides difficile Infection
- Congenital Syphilis
- Cutaneous Bacillus anthracis
- Deep Neck Infection
- Diphtheria
- Endocarditis
- Fusospirochetosis, Trench Mouth
- Gonococcal Infection, Disseminated
- Gram Negative Infection
- Joint Infection
- Leptospirosis
- Lyme Disease, Arthritis
- Lyme Disease, Carditis
- Lyme Disease, Neurologic
- Meningitis
- Meningitis, Meningococcal
- Meningitis, Pneumococcal
- Meningitis, Streptococcus Group B
- Neurosyphilis
- Pneumonia
- Prevention of Perinatal Group B Streptococcal Disease
- Rat-bite Fever
- Septicemia
- Skin or Soft Tissue Infection
- Streptococcal Infection
- Tetanus
Drug and food interactions
ivabradine food
Applies to: Corlanor (ivabradine)
GENERALLY AVOID: Grapefruit juice may significantly increase the plasma concentrations of ivabradine. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. According to the product labeling, administration with grapefruit juice (quantity unknown) resulted in an approximately twofold increase in ivabradine systemic exposure (AUC). Elevated plasma levels of ivabradine may increase the risk of excessive bradycardia and conduction disturbances.
ADJUST DOSING INTERVAL: Food delays the absorption of ivabradine by approximately 1 hour and increases plasma exposure by 20% to 40% compared to fasting conditions.
MANAGEMENT: Patients treated with ivabradine should avoid or limit consumption of grapefruit or grapefruit juice. The manufacturer recommends taking ivabradine with meals to reduce variability in exposure.
References (3)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- (2015) "Product Information. Corlanor (ivabradine)." Amgen USA
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.