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Drug Interactions between colesevelam and odevixibat

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

colesevelam odevixibat

Applies to: colesevelam and odevixibat

ADJUST DOSING INTERVAL: Bile acid binding resins such as cholestyramine colesevelam, or colestipol may bind odevixibat in the gastrointestinal tract, which may reduce odevixibat efficacy.

MANAGEMENT: Odexivibat should be administered at least four hours before or four hours after bile-acid binding resins such as cholestyramine, colestipol, and colesevelam. Patients receiving this combination should be advised to closely follow dosing schedules to prevent loss of therapeutic effects.

References (1)
  1. (2021) "Product Information. Bylvay (odevixibat)." Albireo Pharma, Inc.

Drug and food interactions

Moderate

odevixibat food

Applies to: odevixibat

MONITOR: Odevixibat may affect absorption of fat-soluble vitamins (FSV) including vitamin A, D, E, and K. In clinical studies, new onset or worsening of existing FSV deficiency was reported in 5% of placebo-treated patients, and in 16% of odevixibat-treated 120 mcg/kg/day patients. However, none of the odevixibat-treated 40 mcg/kg/day patients had new onset or worsening of existing FSV deficiency.

MANAGEMENT: Clinical and laboratory monitoring of FSV levels is recommended at baseline and during treatment with odevixibat. If FSV deficiency is diagnosed, supplement with FSV. Odevixibat should be discontinued if FSV deficiency persists or worsens despite adequate FSV supplementation.

References (1)
  1. (2021) "Product Information. Bylvay (odevixibat)." Albireo Pharma, Inc.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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