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Drug Interactions between cobicistat / darunavir and Min-Ovral 21

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

levonorgestrel darunavir

Applies to: Min-Ovral 21 (ethinyl estradiol / levonorgestrel) and cobicistat / darunavir

Darunavir may increase the blood levels and effects of levonorgestrel. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

ethinyl estradiol cobicistat

Applies to: Min-Ovral 21 (ethinyl estradiol / levonorgestrel) and cobicistat / darunavir

Talk to your doctor before using cobicistat together with ethinyl estradiol. Combining these medications may alter the effects of some hormone-based medications. Birth control pills and hormone replacement therapy may become less effective. Also, the risk of side effects such as insulin resistance, lipid disorders, acne, and blood clots may increase. Talk to your gynecologist or other healthcare professional for help in selecting effective methods of birth control that work best for you. If you take hormone replacement for menopause, you should contact your doctor if you experience increased frequency or worsening of your symptoms such as hot flashes, vaginal dryness, or abnormal bleeding. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

levonorgestrel cobicistat

Applies to: Min-Ovral 21 (ethinyl estradiol / levonorgestrel) and cobicistat / darunavir

Talk to your doctor before using cobicistat together with levonorgestrel. Combining these medications may alter the effects of some hormone-based medications. Birth control pills and hormone replacement therapy may become less effective. Also, the risk of side effects such as insulin resistance, lipid disorders, acne, and blood clots may increase. Talk to your gynecologist or other healthcare professional for help in selecting effective methods of birth control that work best for you. If you take hormone replacement for menopause, you should contact your doctor if you experience increased frequency or worsening of your symptoms such as hot flashes, vaginal dryness, or abnormal bleeding. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

levonorgestrel food

Applies to: Min-Ovral 21 (ethinyl estradiol / levonorgestrel)

Grapefruit juice may increase the blood levels of certain medications such as levonorgestrel. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with levonorgestrel. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Moderate

darunavir food

Applies to: cobicistat / darunavir

Food can enhance the levels of darunavir in your body. Take darunavir with food. The type of food does not matter. This will make it easier for your body to absorb the medication. Swallow the whole tablets with a drink such as water or milk. Do not chew the tablets. Darunavir must be always be taken together at the same time as another medication called ritonavir (Norvir).

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Minor

ethinyl estradiol food

Applies to: Min-Ovral 21 (ethinyl estradiol / levonorgestrel)

Information for this minor interaction is available on the professional version.

Minor

ethinyl estradiol food

Applies to: Min-Ovral 21 (ethinyl estradiol / levonorgestrel)

Information for this minor interaction is available on the professional version.

Minor

levonorgestrel food

Applies to: Min-Ovral 21 (ethinyl estradiol / levonorgestrel)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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