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Drug Interactions between coagulation factor Xa and prothrombin complex

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

prothrombin complex coagulation factor Xa

Applies to: prothrombin complex and coagulation factor Xa

GENERALLY AVOID: The safety of andexanet alfa (recombinant coagulation factor Xa) has not been evaluated in patients who received prothrombin complex concentrates, recombinant factor VIIa, or whole blood within seven days prior to the bleeding event, as they were excluded from clinical trials.

MANAGEMENT: Pro-coagulant factor treatments (e.g., 3- or 4-factor prothrombin complex concentrates (PCCs), activated PCC, recombinant factor VIIa, fresh frozen plasma) and whole blood should be avoided during treatment with andexanet alfa unless absolutely required.

References (3)
  1. (2022) "Product Information. Andexxa (coagulation factor Xa)." Portola Pharmaceuticals
  2. (2022) "Product Information. Ondexxya (coagulation factor Xa)." AstraZeneca UK Ltd
  3. (2023) "Product Information. Andexxa (andexanet alfa (factor Xa))." AstraZeneca Pty Ltd

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Anticoagulant reversal agents

Therapeutic duplication

The recommended maximum number of medicines in the 'anticoagulant reversal agents' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'anticoagulant reversal agents' category:

  • coagulation factor Xa
  • prothrombin complex

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer