Drug Interactions between clonazepam and Mucinex Allergy
This report displays the potential drug interactions for the following 2 drugs:
- clonazepam
- Mucinex Allergy (fexofenadine)
Interactions between your drugs
No interactions were found between clonazepam and Mucinex Allergy. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
clonazepam
A total of 520 drugs are known to interact with clonazepam.
- Clonazepam is in the following drug classes: benzodiazepine anticonvulsants, benzodiazepines.
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Clonazepam is used to treat the following conditions:
- Anxiety (off-label)
- Benzodiazepine Withdrawal (off-label)
- Bipolar Disorder (off-label)
- Borderline Personality Disorder (off-label)
- Burning Mouth Syndrome (off-label)
- Chronic Myofascial Pain (off-label)
- Cluster-Tic Syndrome (off-label)
- Epilepsy
- Hyperekplexia (off-label)
- Insomnia (off-label)
- Lennox-Gastaut Syndrome
- Meniere's Disease
- Migraine Prevention (off-label)
- Night Terrors (off-label)
- Obsessive Compulsive Disorder (off-label)
- Panic Disorder
- Periodic Limb Movement Disorder (off-label)
- Primary Orthostatic Tremor (off-label)
- Restless Legs Syndrome (off-label)
- Seizure Prevention
- Seizures
- Sleep Paralysis (off-label)
- Temporomandibular Joint Disorder (off-label)
Mucinex Allergy
A total of 108 drugs are known to interact with Mucinex Allergy.
- Mucinex allergy is in the drug class antihistamines.
- Mucinex allergy is used to treat the following conditions:
Drug and food interactions
fexofenadine food
Applies to: Mucinex Allergy (fexofenadine)
GENERALLY AVOID: Coadministration with large amounts of certain fruit juices, including grapefruit, orange and apple, may decrease the oral bioavailability of fexofenadine. The proposed mechanism is inhibition of drug efflux via intestinal organic anion transporting polypeptides (e.g., P-glycoprotein), of which fexofenadine is a substrate. In a five-way crossover study with 10 healthy volunteers, 1/4-strength grapefruit juice, grapefruit juice, orange juice and apple juice (300 mL with drug administration and 150 mL every 1/2 hour for up to 3 hours, total volume 1.2 L) reduced the mean area under the plasma concentration-time curve (AUC) of a 120 mg dose of fexofenadine by 23%, 67%, 72% and 77%, respectively, compared to water. Mean peak plasma concentration (Cmax) was similarly affected. The clinical significance of these changes is unknown. However, results from studies using histamine-induced skin wheals and flares found that the size of wheal and flare was significantly larger when fexofenadine was administered with either grapefruit or orange juices compared to water.
MANAGEMENT: To maximize plasma levels and therapeutic effects, fexofenadine should be taken with water. In addition, patients should refrain from consuming large amounts of grapefruit, orange, or apple juice.
References
- Bailey DG, Dresser GK, Munoz C, Freemar DJ, Kim RB "Reduction of fexofenadine bioavailability by fruit juices." Clin Pharmacol Ther 69 (2001): PI-82
- Dresser GK, Bailey DG, Leake BF, et al. "Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine." Clin Pharmacol Ther 71 (2002): 11-20
clonazePAM food
Applies to: clonazepam
GENERALLY AVOID: Acute ethanol ingestion may potentiate the CNS effects of many benzodiazepines. Tolerance may develop with chronic ethanol use. The mechanism may be decreased clearance of the benzodiazepines because of CYP450 hepatic enzyme inhibition. Also, it has been suggested that the cognitive deficits induced by benzodiazepines may be increased in patients who chronically consume large amounts of alcohol.
MANAGEMENT: Patients should be advised to avoid alcohol during benzodiazepine therapy.
References
- MacLeod SM, Giles HG, Patzalek G, Thiessen JJ, Sellers EM "Diazepam actions and plasma concentrations following ethanol ingestion." Eur J Clin Pharmacol 11 (1977): 345-9
- Whiting B, Lawrence JR, Skellern GG, Meier J "Effect of acute alcohol intoxication on the metabolism and plasma kinetics of chlordiazepoxide." Br J Clin Pharmacol 7 (1979): 95-100
- Divoll M, Greenblatt DJ, Lacasse Y, Shader RI "Benzodiazepine overdosage: plasma concentrations and clinical outcome." Psychopharmacology (Berl) 73 (1981): 381-3
- Juhl RP, Van Thiel DH, Dittert LW, Smith RB "Alprazolam pharmacokinetics in alcoholic liver disease." J Clin Pharmacol 24 (1984): 113-9
- Ochs HR, Greenblatt DJ, Arendt RM, Hubbel W, Shader RI "Pharmacokinetic noninteraction of triazolam and ethanol." J Clin Psychopharmacol 4 (1984): 106-7
- Staak M, Raff G, Nusser W "Pharmacopsychological investigations concerning the combined effects of dipotassium clorazepate and ethanol." Int J Clin Pharmacol Biopharm 17 (1979): 205-12
- Nichols JM, Martin F, Kirkby KC "A comparison of the effect of lorazepam on memory in heavy and low social drinkers." Psychopharmacology (Berl) 112 (1993): 475-82
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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