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Drug Interactions between cladribine and Pentacel

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

poliovirus vaccine, inactivated cladribine

Applies to: Pentacel (diphtheria toxoid / haemophilus b conjugate (prp-t) vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid) and cladribine

If you are currently being treated or have recently been treated with cladribine, you should let your doctor know before receiving poliovirus vaccine, inactivated. Depending on the dose and length of time you have been on cladribine, you may have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of cladribine therapy. If you have recently been vaccinated with poliovirus vaccine, inactivated, your doctor may choose to postpone treatment with cladribine for a couple of weeks or more. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

tetanus toxoid cladribine

Applies to: Pentacel (diphtheria toxoid / haemophilus b conjugate (prp-t) vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid) and cladribine

If you are currently being treated or have recently been treated with cladribine, you should let your doctor know before receiving tetanus toxoid. Depending on the dose and length of time you have been on cladribine, you may have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of cladribine therapy. If you have recently been vaccinated with tetanus toxoid, your doctor may choose to postpone treatment with cladribine for a couple of weeks or more. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

cladribine diphtheria toxoid

Applies to: cladribine and Pentacel (diphtheria toxoid / haemophilus b conjugate (prp-t) vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid)

If you are currently being treated or have recently been treated with cladribine, you should let your doctor know before receiving diphtheria toxoid. Depending on the dose and length of time you have been on cladribine, you may have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of cladribine therapy. If you have recently been vaccinated with diphtheria toxoid, your doctor may choose to postpone treatment with cladribine for a couple of weeks or more. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

cladribine pertussis, acellular

Applies to: cladribine and Pentacel (diphtheria toxoid / haemophilus b conjugate (prp-t) vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid)

If you are currently being treated or have recently been treated with cladribine, you should let your doctor know before receiving pertussis, acellular. Depending on the dose and length of time you have been on cladribine, you may have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of cladribine therapy. If you have recently been vaccinated with pertussis, acellular, your doctor may choose to postpone treatment with cladribine for a couple of weeks or more. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

cladribine haemophilus b conjugate (PRP-T) vaccine

Applies to: cladribine and Pentacel (diphtheria toxoid / haemophilus b conjugate (prp-t) vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid)

If you are currently being treated or have recently been treated with cladribine, you should let your doctor know before receiving haemophilus b conjugate (PRP-T) vaccine. Depending on the dose and length of time you have been on cladribine, you may have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of cladribine therapy. If you have recently been vaccinated with haemophilus b conjugate (PRP-T) vaccine, your doctor may choose to postpone treatment with cladribine for a couple of weeks or more. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

cladribine food

Applies to: cladribine

Cladribine oral products can bind to other medications. This may increase your risk of experiencing side effects. To avoid or minimize the interaction, cladribine should be taken at least 3 hours before or after other medications. Talk to your doctor if you have any questions or concerns, or if you have trouble separating the dosing times. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.