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Drug Interactions between Cladribine Novaplus and efavirenz / emtricitabine / tenofovir

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

cladribine tenofovir

Applies to: Cladribine Novaplus (cladribine) and efavirenz / emtricitabine / tenofovir

Talk to your doctor before using cladribine together with tenofovir. Some investigators have suggested that medications like tenofovir may reduce the effectiveness of cladribine, although this has not been studied extensively. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

efavirenz tenofovir

Applies to: efavirenz / emtricitabine / tenofovir and efavirenz / emtricitabine / tenofovir

Efavirenz may cause liver problems, and using it with other medications that can also affect the liver such as tenofovir may increase that risk. You should avoid or limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

cladribine emtricitabine

Applies to: Cladribine Novaplus (cladribine) and efavirenz / emtricitabine / tenofovir

Talk to your doctor before using cladribine together with emtricitabine. Some investigators have suggested that medications like emtricitabine may reduce the effectiveness of cladribine, although this has not been studied extensively. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

efavirenz emtricitabine

Applies to: efavirenz / emtricitabine / tenofovir and efavirenz / emtricitabine / tenofovir

Efavirenz may cause liver problems, and using it with other medications that can also affect the liver such as emtricitabine may increase that risk. You should avoid or limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

cladribine food

Applies to: Cladribine Novaplus (cladribine)

Cladribine oral products can bind to other medications. This may increase your risk of experiencing side effects. To avoid or minimize the interaction, cladribine should be taken at least 3 hours before or after other medications. Talk to your doctor if you have any questions or concerns, or if you have trouble separating the dosing times. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

efavirenz food

Applies to: efavirenz / emtricitabine / tenofovir

Taking efavirenz with food increases the amount of medicine in your body, which may increase the frequency of side effects. You should take efavirenz once a day on an empty stomach, preferably at bedtime. Taking it at bedtime may make some side effects such as dizziness, trouble sleeping, drowsiness, trouble concentrating, and/or unusual dreams less bothersome. However, these symptoms may be more severe if efavirenz is used with alcohol or mood-altering (street) drugs. You should avoid driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

tenofovir food

Applies to: efavirenz / emtricitabine / tenofovir

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.