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Drug Interactions between cholera vaccine and teplizumab

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

cholera vaccine teplizumab

Applies to: cholera vaccine and teplizumab

ADJUST DOSING INTERVAL: The administration of inactivated, killed, mRNA or otherwise noninfectious vaccines during teplizumab therapy may be associated with a diminished or suboptimal immunologic response. Vaccination may be less effective during and for up to six weeks after discontinuation of teplizumab therapy.

MANAGEMENT: According to the manufacturer of teplizumab, administration of inactivated, killed, or mRNA vaccinations is not recommended within the 2 weeks prior to, during, or for 6 weeks after treatment with teplizumab. Patients should be advised to receive all age-appropriate vaccinations prior to starting treatment with teplizumab.

References (1)
  1. (2022) "Product Information. Tzield (teplizumab)." Provention Bio, Inc.

Drug and food interactions

Moderate

cholera vaccine food

Applies to: cholera vaccine

ADJUST DOSING INTERVAL: Coadministration of oral cholera vaccine with food or an oral beverage may impair its efficacy. The formulations of both the inactivated and live, attenuated oral cholera vaccines (Dukoral and Vaxchora, respectively) are acid-labile, and must be administered with a buffer. According to the manufacturer, eating and drinking may interfere with the protective effect of the buffer. However, clinical data are not available.

MANAGEMENT: It is recommended that patients avoid eating or drinking for 60 minutes before and after administration of either Dukoral or Vaxchora oral cholera vaccines.

References (4)
  1. (2023) "Product Information. Vaxchora (cholera vaccine, live)." Patientric Ltd
  2. (2022) "Product Information. Dukoral (cholera vaccine, inactivated)." Valneva Sweden AB
  3. (2023) "Product Information. Dukoral (cholera vaccine)." Valneva UK Ltd
  4. (2024) "Product Information. Vaxchora (cholera vaccine, live)." Emergent Travel Health, Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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