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Drug Interactions between cholera vaccine, live and Trovan

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

trovafloxacin cholera vaccine, live

Applies to: Trovan (trovafloxacin) and cholera vaccine, live

If you are currently being treated with trovafloxacin or have been treated within the last 14 days, you should talk to your doctor before receiving cholera vaccine, live. Antibiotics like trovafloxacin may reduce the activity of the vaccine. To ensure adequate vaccine response, you should not receive cholera vaccine, live until at least 14 days after you complete your antibiotic therapy. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

cholera vaccine, live food

Applies to: cholera vaccine, live

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: Coadministration of oral cholera vaccine with food or an oral beverage may impair its efficacy. The formulations of both the inactivated and live, attenuated oral cholera vaccines (Dukoral and Vaxchora, respectively) are acid-labile, and must be administered with a buffer. According to the manufacturer, eating and drinking may interfere with the protective effect of the buffer. However, clinical data are not available.

MANAGEMENT: It is recommended that patients avoid eating or drinking for 60 minutes before and after administration of either Dukoral or Vaxchora oral cholera vaccines.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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