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Drug Interactions between chlorpromazine and Coreg

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

chlorproMAZINE carvedilol

Applies to: chlorpromazine and Coreg (carvedilol)

MONITOR: Some antipsychotic agents and some beta-blockers may mutually inhibit each other's metabolism resulting in increased or additive pharmacologic effects such as hypotension, bradycardia, delirium or seizures. The mechanism may be related to competitive inhibition of CYP450 2D6-mediated first-pass metabolism.

MANAGEMENT: Atenolol, carteolol, or nadolol may be considered as alternatives because they undergo renal elimination and are not expected to interact. If this combination cannot be avoided, decreased dosage of either or both drugs may be necessary and the patient should be closely monitored for cardiovascular or nervous system adverse effects.

References

  1. Peet M, Middlemiss D, Yates R (1980) "Pharmacokinetic interaction between propranolol and chlorpromazine in schizophrenic patients." Lancet, 2, p. 978
  2. Miller F, Rampling D (1982) "Adverse effects of combined propranolol and chlorpromazine therapy." Am J Psychiatry, 139, p. 1198-9
  3. Silver JM, Yudofsky SC, Kogan M, Katz BL (1986) "Elevation of thioridazine plasma levels by propranolol." Am J Psychiatry, 143, p. 1290-2
  4. Vestal RE, Kornhauser DM, Hollifield JW, Shand DG (1979) "Inhibition of propranolol metabolism by chlorpromazine." Clin Pharmacol Ther, 25, p. 19-24
  5. Markowitz JS, Wells BG, Carson WH (1995) "Interactions between antipsychotic and antihypertensive drugs." Ann Pharmacother, 29, p. 603-9
View all 5 references

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Drug and food interactions

Moderate

chlorproMAZINE food

Applies to: chlorpromazine

GENERALLY AVOID: Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment. Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines. The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.

MANAGEMENT: Patients should be advised to avoid alcohol during phenothiazine therapy.

References

  1. Lutz EG (1976) "Neuroleptic-induced akathisia and dystonia triggered by alcohol." JAMA, 236, p. 2422-3
  2. Freed E (1981) "Alcohol-triggered-neuroleptic-induced tremor, rigidity and dystonia." Med J Aust, 2, p. 44-5

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.