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Actifed Cold and Allergy (chlorpheniramine / phenylephrine) Drug Interactions

A total of 903 drugs are known to interact with Actifed Cold and Allergy (chlorpheniramine / phenylephrine).

  • 194 major drug interactions
  • 703 moderate drug interactions
  • 6 minor drug interactions

Show all medications in the database that may interact with Actifed Cold and Allergy (chlorpheniramine / phenylephrine).

Check for interactions

Type in a drug name to check for interactions with Actifed Cold and Allergy (chlorpheniramine / phenylephrine).

Most frequently checked interactions

View interaction reports for Actifed Cold and Allergy (chlorpheniramine / phenylephrine) and the medicines listed below.

  • Advil (ibuprofen)
  • aspirin (Aspir 81, Ecotrin, Aspirin Low Strength, Acetylsalicylic Acid, Bayer Aspirin, Aspir-Low, Bufferin, Ascriptin, Arthritis Pain, Aspiritab, Aspergum, Fasprin, Halfprin, Easprin, Ecotrin Adult Low Strength, Empirin, Migralex, Aspi-Cor, St. Joseph 81 mg Chewable Aspirin, Bayer Children's Aspirin, Buffered Aspirin, Durlaza, Ecotrin Maximum Strength, Entercote, Bufferin Extra Strength, Ascriptin Enteric, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspirtab, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Low Dose ASA, Bayer Aspirin Extra Strength Plus, Buffex, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, St. Joseph Aspirin, Stanback Analgesic, Norwich Aspirin, Acuprin 81, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Aspirin Lite Coat, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Benadryl (diphenhydramine)
  • Daily Multi-Vitamins with Minerals (multivitamin with minerals)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Sleep, Unisom SleepGels, Sominex, Sleep Tabs, Benadryl Children's Allergy, Dicopanol, Diphen, Nytol, Simply Sleep, Diphenhist, Hydramine, Diphenydramine Quick Melt, Sleepwell 2-nite, Hydramine Cough Syrup, Bydramine, Diphedryl, DPH, Calm-Aid, Diphenadryl, Sleep Tab II, Diphenyl, Altaryl, Quenalin, Diphendryl, Sleep-ettes D, Dytan, Vanamine PD, Unisom SleepMelts, Dormin, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Buckley's Bedtime, Hyrexin, 40 Winks, Diphen AF, Diphen Cough, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Genahist, Alka-Seltzer Plus Allergy, Q-Dryl, Aller-G-Time, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Uni-Tann, Q-Dryl A/F, Diphenmax, Nightime Sleepaid, Ben-Tann, Pharbedryl, Histaprin, Z-Sleep, Tranquil Nighttime Sleep Aid, PediaCare Children's Allergy, Truxadryl, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Euthyrox, Unithroid, Levothyrox, Eutroxsig, Levo-T, Oroxine, L Thyroxine Roche, Levotabs, Novothyrox, Tirosint-Sol, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • loratadine (Claritin, Alavert, Claritin 24 Hour Allergy, Loratadine Reditab, Allergy Relief Tablets, Allergy Relief 24 Hour, Claritin Reditabs, Wal-itin, Children's Allergy Relief 24 Hour, Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief, Help I Have Allergies, ohm Allergy Relief, Clear-Atadine, Claritin Hives Relief, Dimetapp Children's ND Non-Drowsy Allergy, Clear-Atadine Children's, Bactimicina Allergy, Tavist ND, Children's Claritin Allergy)
  • magnesium oxide (Mag-Ox 400, Mag-Oxide, Mag-Ox, Uro-Mag, Mag-200, MagGel, Phillips' Cramp-free, Mag-Caps)
  • metformin (Glucophage, Glumetza, Glucophage XR, Fortamet, Riomet)
  • Norvasc (amlodipine)
  • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, RoxyBond, Percolone, Oxecta, Oxydose, Oxyfast, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol, Dazidox)
  • sertraline (Zoloft)
  • Singulair (montelukast)
  • Synthroid (levothyroxine)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin D3 (cholecalciferol)

Actifed Cold and Allergy (chlorpheniramine / phenylephrine) alcohol/food interactions

There is 1 alcohol/food interaction with Actifed Cold and Allergy (chlorpheniramine / phenylephrine)

Actifed Cold and Allergy (chlorpheniramine / phenylephrine) disease interactions

There are 8 disease interactions with Actifed Cold and Allergy (chlorpheniramine / phenylephrine) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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