Drug Interactions between chloramphenicol and Yasmin

Chloramphenicol may increase the blood levels and effects of ethinyl estradiol. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects, such as changes in weight and/or appetite, dizziness, headaches, upset stomach, nausea, vomiting, bloating, and/or bleeding between menstrual cycles. Seek immediate medical care if you experience any of the following, as they could indicate that you are experiencing a serious side effect: dark urine; light-colored stools; yellow skin or eyes; very bad headache or dizziness; passing out; change in eyesight or a change in how contact lenses feel; severe upset stomach; severe vomiting; pain in the upper right belly area, right shoulder area, or between the shoulder blades; chest pain or pressure; coughing up blood; trouble breathing; swelling, warmth, numbness, change of color or pain in a leg or arm; trouble speaking or swallowing; depression or other mood changes; a lump in the breast; breast pain or soreness; nipple discharge; bone pain; and/or muscle cramps or spasms.

On the other hand, antibiotics such as chloramphenicol can also reduce the amount of estrogen available in the body from estrogen containing hormonal medications. If you are using an estrogen containing medication for birth control, you may be at increased risk for pregnancy or breakthrough bleeding. Be sure to alert your doctor if you are having any vomiting and/or diarrhea as this too can impact how well your hormonal birth control works. Talk to your doctor or pharmacist to determine if you should use an alternative or additional form of birth control during or after treatment with chloramphenicol. If you are using an estrogen containing medication for a purpose other than birth control, discuss any questions you may have or any changes you notice regarding how well your medication is working with your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Chloramphenicol may increase the blood levels of drospirenone in some patients. This can increase the risk of developing hyperkalemia, or high levels of potassium in the blood, which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. Hyperkalemia is usually more likely to occur in people who are dehydrated or have kidney disease, diabetes, or advanced heart failure. Regular or long-term use of nonsteroidal anti-inflammatory drugs such as ibuprofen or naproxen (Aleve), or prescription medications such as potassium supplements or certain medications used to treat high blood pressure or heart conditions, may also increase the risk. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat, as these may be symptoms of hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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