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Drug Interactions between ceftobiprole medocaril and letermovir

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

ceftobiprole letermovir

Applies to: ceftobiprole medocaril and letermovir

GENERALLY AVOID: Coadministration with ceftobiprole may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of organic anion transporting polypeptide (OATP) 1B1 and/or OATP1B3. The proposed mechanism is decreased clearance due to ceftobiprole-mediated inhibition of OATP1B1 and/or OATP1B3.

MANAGEMENT: Concomitant use of ceftobiprole with drugs that are substrates of OATP1B1 and/or OATP1B3 is not recommended. Clinical and laboratory monitoring may be appropriate whenever ceftobiprole is added to or withdrawn from therapy with these drugs. Dosage adjustments may be considered if an interaction is suspected. Patients should be monitored for the development of adverse effects.

References (12)
  1. (2001) "Product Information. Pravachol (pravastatin)." Bristol-Myers Squibb
  2. (2001) "Product Information. Zocor (simvastatin)." Merck & Co., Inc
  3. (2001) "Product Information. Lipitor (atorvastatin)." Parke-Davis
  4. (2003) "Product Information. Crestor (rosuvastatin)." AstraZeneca Pharma Inc
  5. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  6. Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
  7. Neuvonen PJ, Niemi M, Backman JT (2006) "Drug interactions with lipid-lowering drugs: Mechanisms and clinical relevance." Clin Pharmacol Ther, 80, p. 565-81
  8. Cerner Multum, Inc. "Australian Product Information."
  9. Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
  10. Cerner Multum, Inc. (2015) "Canadian Product Information."
  11. Morival C, Westerlynck R, Bouzille G, Cuggia M, Le Corre P (2018) "Prevalence and nature of statin drug-drug interactions in a university hospital by electronic health record mining." Eur J Clin Pharmacol, 74, p. 525-534
  12. Hua WJ, Hua WX, Fang HJ (2012) "Role of OATP1B1 in pharmacokinetics and DDI of novel statins." Cardiovasc Ther, 30, e234-41

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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