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Drug Interactions between capivasertib and Depacon

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

valproic acid capivasertib

Applies to: Depacon (valproic acid) and capivasertib

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with inhibitors of uridine diphosphate glucuronosyltransferase (UGT) 2B7 may increase the plasma concentrations and effects of capivasertib, which is a substrate of the isoenzyme. Based on physiologically based pharmacokinetic models, concomitant use with UGT2B7 inhibitor, probenecid is predicted to cause an increase in capivasertib systemic exposure (AUC) of 37% over a dosing cycle. However, the clinical significance of this effect is unknown.

MANAGEMENT: Caution is advised if capivasertib is used concurrently with medications that are inhibitors of UGT2B7. Clinical and laboratory monitoring may be appropriate for capivasertib whenever these drugs are added to or withdrawn from therapy. The prescribing information for the concomitant medication(s) may be consulted for further guidance.

Drug and food/lifestyle interactions

Major

capivasertib food/lifestyle

Applies to: capivasertib

Consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit should be avoided during treatment with capivasertib as they may increase the blood levels of capivasertib. This may increase the risk of side effects such as high blood sugar levels, diarrhea, skin reactions, nausea, vomiting, tiredness, and changes in certain blood tests. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

valproic acid food/lifestyle

Applies to: Depacon (valproic acid)

Alcohol can increase the nervous system side effects of valproic acid such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with valproic acid. Do not use more than the recommended dose of valproic acid, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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